# Analytical Services Core

> **NIH NIH P30** · UNIVERSITY OF KENTUCKY · 2021 · $202,162

## Abstract

PROJECT SUMMARY- ANALYTICAL CORE
The overarching goal of the Analytical Core is to improve the capacity, quality, efficiency and cost-
effectiveness of environmental disease research at the University of Kentucky (UK). This will be achieved by
providing UK-Center for Appalachian Research in Environmental Science (UK-CARES) researchers with
premium access to expert advice, consultation and technical support to develop and validate analytical
methods using state-of-the-art technologies for studies spanning the range of environmental disease research
areas represented in the center. These services are needed to detect and measure environmental pollutants
and biomarkers of environmental exposures, which requires sophisticated instrumentation and technical
expertise that is unavailable to individual investigators. Our partner facility cores, the Small Molecule Mass
Spectrometry Core laboratory (SMMSC) and Resource Center for Stable Isotope Resolved Metabolomics (RC-
SIRM), can provide the entire range of analytical capabilities required for state-of-the-art environmental
disease research. However, effective use of these facilities by environmental disease researchers often
requires new method development, validation and pilot studies to establish analyte levels and technical
reproducibility. The properties of the target analytes and the need to measure them at low levels in
environmental and biological samples frequently present unique challenges for sample preparation. With
validated analytical methods in hand data analysis can be challenging, particularly since biological and health
outcomes are dictated by exposures to multiple agents often requiring precise, accurate and simultaneous
measurements of multiple analytes or biomarkers of environmental exposures and informatics approaches to
enable integrated analysis of large data sets. The Analytical Core addresses these limitations by providing
consultation in the design, execution and interpretation of studies that require use of advanced analytical
instrumentation for environmental disease research. The core staff will then develop and validate sample
preparation and analytical methods for detection and quantitation of environmental pollutants and biomarkers
in complex samples and provide consultation and assistance with statistical methods for the analysis of
datasets generated using these analytical methods. Finally the Analytical Core will provide education and
training in analytical and data analysis methods for environmental disease research through personal outreach,
courses and workshops, enabling integration of analytical and metabolomics technologies into the research of
UK-CARES members. Overall, the Analytical Core will add considerable value to environmental disease
research at UK by leveraging existing institutional and NIH investments in research infrastructure to achieve
the goals of our UK-CARES research team.

## Key facts

- **NIH application ID:** 10135070
- **Project number:** 5P30ES026529-05
- **Recipient organization:** UNIVERSITY OF KENTUCKY
- **Principal Investigator:** ANDREW J MORRIS
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $202,162
- **Award type:** 5
- **Project period:** 2017-05-01 → 2023-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10135070

## Citation

> US National Institutes of Health, RePORTER application 10135070, Analytical Services Core (5P30ES026529-05). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10135070. Licensed CC0.

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