# Novel Regulatory Mechanisms Underlying Inside-out Integrin Activation

> **NIH NIH R35** · RESEARCH INST OF FOX CHASE CAN CTR · 2020 · $39,187

## Abstract

Project Summary
 This is a request for an NIGMS Administrative Supplement to NIGMS grant R35GM119560, to purchase
an ÄKTA Pure 25L chromatography system. The PI’s current chromatography system is heavily utilized, and this
represents the rate-limiting step for further progress in this already-successful project. We currently rely on an
older instrument that has been discontinued by the manufacturer and can no longer be supported for repairs as
needed. This is a joint request with another NIGMS-funded investigator, Dr. John Karanicolas, whose research
group has also exceeded their chromatography capabilities and who also relies on a nearly-identical older
instrument. Access to the requested ÄKTA Pure 25L chromatography system will provide the necessary
capabilities to maximize productivity and fully achieve the aims of both NIGMS-sponsored research projects.
Institutional matching funds will contribute to the purchase of this instrument.

## Key facts

- **NIH application ID:** 10135349
- **Project number:** 3R35GM119560-04S1
- **Recipient organization:** RESEARCH INST OF FOX CHASE CAN CTR
- **Principal Investigator:** Jinhua Wu
- **Activity code:** R35 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $39,187
- **Award type:** 3
- **Project period:** 2016-09-01 → 2021-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10135349

## Citation

> US National Institutes of Health, RePORTER application 10135349, Novel Regulatory Mechanisms Underlying Inside-out Integrin Activation (3R35GM119560-04S1). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10135349. Licensed CC0.

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