# Fis1 Regulation of Mitochondrial Fission

> **NIH NIH R01** · MEDICAL COLLEGE OF WISCONSIN · 2020 · $111,069

## Abstract

Project Summary/Abstract
The goal of this administrative supplement request is to provide a state-of-the-art circular dichroism
spectrophotometer for biophysical studies on mitochondrial fission proteins for R01GM067180. Altered
mitochondrial fission has severe consequences even death. Yet the reasons for this are unknown. It is
postulated that the mitochondria have their own lifecycle that involves fission of unhealthy mitochondria to
remove them. In this model, the proper balance of fission is critical: either excess or impaired fission both result
in unhealthy mitochondria. This model is compelling because it explains how alterations in fission can cause or
contribute to many fundamentally different diseases including recovery from heart attack and stroke, increased
metabolic stress from diabetes, normal aging, and neurodegenerative diseases such as Parkinson's and
Alzheimer's disease. To understand the protein-protein interactions that govern this, biochemical and structural
studies have identified mutations that will be measured for altered folding and thermodynamic stability using
the requested instrumentation. A better understanding of the protein machinery and how it works will identify
key points of regulation that may be targeted with small molecules to inhibit, and activate, fission. The
discovery of such molecules may ultimately lead to treatments for diseases in which enhanced, or impaired,
fission is central.

## Key facts

- **NIH application ID:** 10135559
- **Project number:** 3R01GM067180-16S1
- **Recipient organization:** MEDICAL COLLEGE OF WISCONSIN
- **Principal Investigator:** R Blake Hill
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $111,069
- **Award type:** 3
- **Project period:** 2004-01-01 → 2023-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10135559

## Citation

> US National Institutes of Health, RePORTER application 10135559, Fis1 Regulation of Mitochondrial Fission (3R01GM067180-16S1). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10135559. Licensed CC0.

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