# Protocol Review and Monitoring System

> **NIH NIH P30** · JOHNS HOPKINS UNIVERSITY · 2021 · $93,338

## Abstract

ABSTRACT
The primary role of the Protocol Review and Monitoring System-Clinical Research Review Committee (PRMS-
CRC) of the Sidney Kimmel Comprehensive Cancer Center (SKCCC) at Johns Hopkins is to provide rigorous
internal scientific review of all human subjects cancer-related protocols within the institution, in accordance with
National Cancer Institute Cancer Center Support Grant Guidelines. The Committee is responsible for reviewing
the scientific merit, priorities and progress of the clinical research of the SKCCC. The Committee has the
authority to approve protocols for IRB review that meet the scientific merit and priorities of the SKCCC and to
close protocols that do not demonstrate adequate scientific progress. The PRMS-CRC is supported by the
Clinical Protocol and Data Management Office (CPDM).
The primary role of the PRMS-CRC of the SKCCC is to provide scientific review and prioritization of all
protocols within the Cancer Center and it has the authority to forward protocols for IRB review and to close
protocols that do not demonstrate scientific progress
The PRMS performs a two-stage review of study protocols. The PRMS-CRC Pre-Review Subcommittee
reviews studies for aspects critical to the study's execution, whereas the PRMS-CRC reviews the scientific
aspects of a study.
The PRMS is distinct and independent in terms of function and leadership from the CPDM and the Data Safety
and Monitoring Committee (DSMC).

## Key facts

- **NIH application ID:** 10135902
- **Project number:** 5P30CA006973-58
- **Recipient organization:** JOHNS HOPKINS UNIVERSITY
- **Principal Investigator:** Michael A Carducci
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $93,338
- **Award type:** 5
- **Project period:** 1997-05-07 → 2022-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10135902

## Citation

> US National Institutes of Health, RePORTER application 10135902, Protocol Review and Monitoring System (5P30CA006973-58). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10135902. Licensed CC0.

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