# Cancer Molecular and Functional Imaging Program - 04

> **NIH NIH P30** · JOHNS HOPKINS UNIVERSITY · 2021 · $36,924

## Abstract

ABSTRACT
The overall goal of the Sidney Kimmel Comprehensive Cancer Center (SKCCC) Cancer Molecular and
Functional Imaging (CMFI) Program is to use molecular and functional imaging to identify novel, imaging-
based targets and advance translational applications in biomarker and drug development and treatment. To
achieve this overall goal, the CMFI Program has the following four aims that focus on cancer biology and
discovery, imaging agent development, biomarkers and clinical evaluation of therapies, target delineation, and
drug delivery: (1) To use multimodality molecular and functional imaging to understand cancer and the tumor
microenvironment; (2) To integrate chemistry and molecular biology with imaging to develop novel imaging
probes, with an emphasis on clinical translation; (3) To develop noninvasive biomarkers to allow early
identification of cancer, predict risk, assist in the selection of treatment and detect response; and (4) To use
imaging to determine drug delivery. Over the past five years, this aim has significantly expanded to include
developing theranostic agents, a key component of the Program's future directions. The identification of
specific targets in cancer drives advances in novel, image-guided platforms, such as liposomes and
nanoplexes, to delivery siRNA or cDNA to silence or upregulate specific targets and pathways. As a result, the
four aims are interrelated within the CMFIP and among other Programs, such as Cancer Biology (CB), Breast
and Ovarian Cancer (BOC), and Prostate Cancer (PC).
Currently, the CMFI Program has 27 members and expertise that reflects the four Program elements. CMFI
Program members have primary appointments in the departments of Radiology and Radiological Science,
Biomedical Engineering, and Chemical and Biomolecular Engineering, and hold appointments in four
graduate programs. Nineteen faculty members have peer-reviewed funding. A majority of the faculty is
housed in the SKCCC Cancer Research Buildings I and II (CRBI/II) complex, and the Program is home to
approximately 10 graduate students and 15 Postdoctoral fellows. The Program is supported by $19.8 million
total costs of sponsored funding, of which $18.6 million is peer-reviewed. The Program has major
interactions with the BOC, PC, Brain Cancer (BC), and Hematologic Malignancies and Bone Marrow
Transplantation (HMBMT) Programs, and is expanding into research of pancreatic cancer and lung cancer.
The were 617 publications in the CMFI Program. Of these, 202 (33%) were Intra-Programmatic, 148 (24%)
were Inter-Programmatic and 149 (24%) publications were multi-institutional collaborations.

## Key facts

- **NIH application ID:** 10135908
- **Project number:** 5P30CA006973-58
- **Recipient organization:** JOHNS HOPKINS UNIVERSITY
- **Principal Investigator:** Zaver M. Bhujwalla
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $36,924
- **Award type:** 5
- **Project period:** 1997-05-07 → 2022-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10135908

## Citation

> US National Institutes of Health, RePORTER application 10135908, Cancer Molecular and Functional Imaging Program - 04 (5P30CA006973-58). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10135908. Licensed CC0.

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