# Brain Cancer Program - 09

> **NIH NIH P30** · JOHNS HOPKINS UNIVERSITY · 2021 · $55,386

## Abstract

ABSTRACT
The Sidney Kimmel Comprehensive Cancer Center's (SKCCC's) Brain Cancer (BC) Program was established
in 2005, recognizing a unique opportunity to blend multiple facets of brain tumor research to improve diagnostic
and therapeutic approaches in these difficult cancers. It brought together the activities of an extremely strong
brain tumor clinical, clinical research and training program, and an expanding group of investigators exploring
the basic biology of brain neoplasia. It includes 20 members from seven departments within the Johns Hopkins
University School of Medicine. National Cancer Institute (NCI) and other peer-reviewed support of Program
members total $6.9 million annually, with an additional $5.6 million annually in nonpeer-reviewed funding. The
research portfolio of the Program has been supported by multiple peer-reviewed grants, including 22 years of
continual NIH funding for a Phase I/II clinical trial group (The New Approaches to Brain Tumor Therapy CNS
Consortium [NABTT] from 1994-2008 and the Adult Brain Tumor Consortium [ABTC] from 2009–2019) and
three active formal training programs to prepare Postdoctoral fellows, from multiple disciplines, for an academic
career in brain tumor research. Eleven members have peer-reviewed funding. Peer reviewed publications by
Program members totaled 535—177 (33%) were Intra-Programmatic, 91 (17%) were Inter-Programmatic and
118 (22%) were multi-institutional collaborations. The BC Program is focused on three specific aims that bridge
laboratory and clinical efforts:
Aim 1: Explore novel immunologic approaches to improve survival in patients with glioblastoma.
Aim 2: Develop novel biomarkers to monitor the progression and response of malignant brain tumors.
Aim 3: Identify genomic and molecular regulators of brain tumor oncogenesis and novel therapeutic targets
(brain cancer biology).
These research efforts are directed by international experts in the brain tumor field who have a long and
productive history of working together to bring important therapeutic and diagnostic projects from inception to
bedside. The infrastructure of the BC Program ensures careful monitoring of the Program's focus,
productivity and priorities. It provides formal interactions to maximize collaborative research efforts and
support the conduct of innovative and high-quality clinical and translational research.

## Key facts

- **NIH application ID:** 10135915
- **Project number:** 5P30CA006973-58
- **Recipient organization:** JOHNS HOPKINS UNIVERSITY
- **Principal Investigator:** STUART A GROSSMAN
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $55,386
- **Award type:** 5
- **Project period:** 1997-05-07 → 2022-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10135915

## Citation

> US National Institutes of Health, RePORTER application 10135915, Brain Cancer Program - 09 (5P30CA006973-58). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10135915. Licensed CC0.

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