# Atlas55+: Creation and Validation of a Reference Brain Functional Atlas for Late Adulthood

> **NIH NIH R03** · FATHER FLANAGAN'S BOYS' HOME · 2020 · $77,500

## Abstract

PROJECT SUMMARY
Older individuals represent 15% of the United States population, and this is expected to exceed 20% by 2050.
It is therefore critical that we improve our understanding of the physiology of healthy brain aging and the
mechanisms that may lead to dysfunction in older people. It is well accepted that the brain is functionally
organized into multiple interacting networks. The reliable and reproducible identification of brain functional
networks crucially depends on the use of reference functional atlases. Extensive literature has demonstrated
that the spatial and functional organization of the brain connectome shows age-related alterations in later life.
Yet, there is currently no reference brain functional atlas derived from older adults, and this may undermine the
validity and reliability of neuroimaging research in late adulthood. Using pilot data for this application, we show
that an age-appropriate brain functional atlas will improve the characterization of the brain functional
connectome and its links to cognition in late adulthood. In this context, the aim of this application is to construct
and validate the first reference brain functional atlas in healthy adults above the age of 55 years. To achieve
this, we will use resting-state functional magnetic resonance imaging (rs-fMRI) from three large, independent
and publicly available neuroimaging datasets. Our first aim (Aim 1) is to generate a reference atlas, called
“Atlas55+”, using the largest rs-fMRI dataset currently available from the Cambridge Centre for Ageing and
Neuroscience (CamCAN) repository (n=326). We will demonstrate the replicability of Atlas55+ in two
independent large samples of older healthy participants derived from the Alzheimer's Disease Neuroimaging
Initiative (ADNI, n=200) and the Southwest University Adult Lifespan Dataset (n=191) (Aim 2). Because
women, on average, have a longer life expectancy than men, we will test whether older women show brain
network differences compared to older men. In the event of significant sex differences, we will create the first
sex-specific brain functional atlases in older adults (Aim 3). Fourth, we will demonstrate the superiority of
network connectivity features derived from Atlas55+ compared to an atlas based on data from younger people
in predicting a greater amount of the variance in fluid intelligence in healthy older adults and in Mini Mental
Status Examination score in patients with Alzheimer's disease or mild cognitive impairment (Aim 4). The
successful completion of this project will provide the first reliable brain functional atlas for adults over the age of
55 years which will be made freely available to other researchers. By mapping the brain functional connectome
underlying late adulthood, this work has the potential to elucidate how dysfunction of the brain networks
contributes to neurodegenerative conditions.

## Key facts

- **NIH application ID:** 10136288
- **Project number:** 7R03AG064001-03
- **Recipient organization:** FATHER FLANAGAN'S BOYS' HOME
- **Principal Investigator:** Gaelle Eve Doucet
- **Activity code:** R03 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $77,500
- **Award type:** 7
- **Project period:** 2019-08-01 → 2022-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10136288

## Citation

> US National Institutes of Health, RePORTER application 10136288, Atlas55+: Creation and Validation of a Reference Brain Functional Atlas for Late Adulthood (7R03AG064001-03). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10136288. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*