# An Integrative Science Approach to Resilience: The Notre Dame Study of Health & Well-being

> **NIH NIH UH3** · UNIVERSITY OF NOTRE DAME · 2021 · $623,278

## Abstract

Project Summary
This proposal is designed to investigate the myriad pathways through which life stress contributes to the
cognitive, physical and mental health across the adult lifespan, and of the resilience mechanisms that may
protect individuals from the ill-effects of exposure to adversity. We plan to collect in-person cognitive and
health data from ## individuals participating in the Notre Dame Study of Health & Well-Being (NDHWB) who
have at least 7 years of longitudinal questionnaire data and 4 bursts of 56-day daily diary data. A second
objective is to add a laboratory-based experimental stress manipulation to pilot a) optimal methods to
experimentally manipulate stress, b) the assessment of subsequent disruption to physiological systems
affected by stress (e.g., cortisol, alpha amylase, heart rate, facial expressions), and c) the appraisal of coping
resources that differentiate the regulation of stress response. We will capitalize on the unique scientific value
of the NDHWB to pursue a broad agenda of research on risk and resilience across adulthood.

## Key facts

- **NIH application ID:** 10136498
- **Project number:** 5UH3AG057039-05
- **Recipient organization:** UNIVERSITY OF NOTRE DAME
- **Principal Investigator:** Cindy S Bergeman
- **Activity code:** UH3 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $623,278
- **Award type:** 5
- **Project period:** 2017-09-15 → 2025-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10136498

## Citation

> US National Institutes of Health, RePORTER application 10136498, An Integrative Science Approach to Resilience: The Notre Dame Study of Health & Well-being (5UH3AG057039-05). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10136498. Licensed CC0.

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