# Expanding access to open-source data acquisition software for next-generation silicon probes

> **NIH NIH U24** · ALLEN INSTITUTE · 2021 · $473,610

## Abstract

We plan to provide software support services for Neuropixels probes, a groundbreaking new tool for recording
electrical signals from the brain. These probes—which were created by IMEC, a world-renowned
nanoelectronics research center, in collaboration with four funding agencies (HHMI, Allen Institute, Gatsby
Foundation, and Wellcome Trust)—will become publicly available in July 2018. Each device consists of a
single hair-like shank containing nearly 1000 recording sites, each of which can measure voltage changes with
sub-millisecond precision. Not only can these probes simultaneously record action potentials from an order of
magnitude more neurons than was previously possible, but the entire package is small enough to be mounted
on the head of a freely moving rodent. Given the relatively low cost of these reusable probes, they will become
a new standard for electrophysiology. In order to use Neuropixels for our own experiments, the Allen Institute
made it possible to stream Neuropixels data into an existing open-source software package, Open Ephys.
Funding for this proposal would allow us to hire personnel to provide community-wide support for the
integration of Open Ephys and Neuropixels. Support functions would include responding to user requests,
maintaining the source code, improving the documentation, and simplifying the processing of installing and
upgrading the software. This would serve to make Neuropixels accessible to all laboratories, regardless of their
prior experience with electrophysiology. In addition, we plan to gather software plugins developed by users,
make them more robust, and disseminate them through a centralized repository. Open Ephys already has a
global network of volunteer developers, which we plan to leverage to expand the features of this software.
Throughout the process, we will engage with the community via interviews, surveys, conferences, and annual
workshops. While our main focus will be on providing support services for Neuropixels users, our efforts will
also benefit the broader electrophysiology community. The field is currently lacking open standards for data
acquisition, analysis, and visualization, leading to a large amount of redundant development efforts across
laboratories. Establishing long-term support for a flexible, powerful, and open-source software platform would
provide a terrific foundation for future progress. Thanks to Open Ephys’ modular plugin architecture, it will be
easy to adapt when the next technological breakthrough occurs.

## Key facts

- **NIH application ID:** 10136734
- **Project number:** 5U24NS109043-03
- **Recipient organization:** ALLEN INSTITUTE
- **Principal Investigator:** Joshua H Siegle
- **Activity code:** U24 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $473,610
- **Award type:** 5
- **Project period:** 2019-04-15 → 2024-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10136734

## Citation

> US National Institutes of Health, RePORTER application 10136734, Expanding access to open-source data acquisition software for next-generation silicon probes (5U24NS109043-03). Retrieved via AI Analytics 2026-05-21 from https://api.ai-analytics.org/grant/nih/10136734. Licensed CC0.

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