Statistical methods to localize disease heritability and identify biological mechanisms

NIH RePORTER · NIH · R37 · $226,177 · view on reporter.nih.gov ↗

Abstract

PROJECT SUMMARY/ABSTRACT An estimate of genetic ancestry is typically included as a control in a genetic association test. This estimate of ancestry dovetails closely with conceptualization of human populations in genetic analysis. Other fields have different ways and different motivations for grouping individuals into populations, such as the OMB categories for race. From a social science point of view the stakes are high; they fear that the way statistical geneticists are starting to use the concept of ancestry will end up reifying race as a biological category. This project aims first to describe, using a schema that we will develop, how the population concept is used across different disciplines relevant to the study of genetic associations. This will help identify points of tension. We will attempt to resolve these through a normative project that refines this schema by identifying how the terms should be used. This will be an interdisciplinary endeavor resulting in guidelines for use of the population and ancestry concepts across these disciplines.

Key facts

NIH application ID
10136834
Project number
3R37MH107649-06S1
Recipient
BROAD INSTITUTE, INC.
Principal Investigator
Anna Lewis
Activity code
R37
Funding institute
NIH
Fiscal year
2020
Award amount
$226,177
Award type
3
Project period
2015-07-01 → 2023-05-31