# Adaptive Treatment Models for the Management of Drug Use Disorders

> **NIH NIH K24** · UNIVERSITY OF PENNSYLVANIA · 2021 · $177,902

## Abstract

In this K24 renewal application, I am seeking funding to continue support for my mentoring activities in
patient oriented research (POR), engage in further career development activities, conduct POR with mentees,
and conduct three pilot studies that expand the aims of my current grants. My work is focused on the devel-
opment, evaluation, and dissemination of adaptive, patient-oriented treatment models across the continuum of
care for substance use disorders (SUD). Much of this work is concerned with identifying the treatment compo-
nents and features that promote sustained participation and better outcomes, including adaptive protocols that
address patient nonresponse, mobile health communication technology, and incentives.
 I will continue to mentor postdoctoral fellows and new clinician investigators at UPENN, the Treatment
Research Institute (TRI), and other institutions, and will add additional mentees. This work will include time
spent in planning, reviewing, and providing feedback on manuscripts and grant applications; giving career
counseling; and providing further training in the design and evaluation of adaptive treatment interventions for
substance use disorders, sequential multiple assignment randomized trial (SMART) designs, and mobile health
technology. For this renewal, mentees will include a number of junior faculty members from the University of
Michigan (UMICH), with interest in adaptive treatment, SMART designs, and continuing care.
 With regard to career development, I will obtain additional knowledge in behavioral econom-
ics/incentives, new developments in adaptive treatments and SMART designs, and mobile health technology.
To that end, I will attend workshops at UPENN at the Center for Health Incentives and Behavioral Economics,
and consult with current collaborators at the University of Connecticut (UCONN; Dr. Nancy Petry), University of
Wisconsin (UWISC; Dr. David Gustafson), UMICH (Dr. Susan Murphy), and North Shore Long Island Jewish
Health System (NSLIJHS; Drs. Jon Morgenstern and Fred Muench) who are experts in these areas.
 I am currently the PI of a NIAAA R01 and a DoD grant equivalent to an R01, and a co-investigator on a
NIDA R01 awarded to Dr. Alan Budney at Dartmouth and on a NIAAA R01 awarded to Dr. Jon Morgenstern at
NSLIJHS. All of these projects are randomized clinical trials. My NIAAA R01 is testing the relative efficacy
and cost-effectiveness of telephone continuing care, an automated smartphone recovery app, and an integrat-
ed protocol that combines these two interventions. The DoD grant is evaluating the efficacy of an adaptive
prevention intervention designed to reduce hazardous alcohol and benzodiazepine use in veterans taking opi-
oid medications for pain. Funds are requested to conduct three pilot studies addressing: (1) Counselor percep-
tions of use and value of mobile technology as a clinician extender in SUD treatment, (2) Patient use of differ-
ent mobile heath technology functions and their co...

## Key facts

- **NIH application ID:** 10137200
- **Project number:** 5K24DA029062-10
- **Recipient organization:** UNIVERSITY OF PENNSYLVANIA
- **Principal Investigator:** JAMES R. MCKAY
- **Activity code:** K24 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $177,902
- **Award type:** 5
- **Project period:** 2010-09-01 → 2024-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10137200

## Citation

> US National Institutes of Health, RePORTER application 10137200, Adaptive Treatment Models for the Management of Drug Use Disorders (5K24DA029062-10). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10137200. Licensed CC0.

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