# Mouse Phenotyping, Physiology, and Metabolism Core

> **NIH NIH P30** · UNIVERSITY OF PENNSYLVANIA · 2021 · $216,777

## Abstract

Our understanding of the pathogenesis of diabetes, obesity and other metabolic disorders has benefited
greatly from the use of dietary interventions and gene targeting methodology in mice to elucidate molecular
mechanisms. However, such efforts are often hampered by a lack of facilities or expertise for metabolic
phenotyping. The Mouse Phenotyping, Physiology and Metabolism Core provides investigators of the Penn
Diabetes and Endocrinology Research Center (DRC) with access to state-of-the-art, timely and cost-effective
resources for performing metabolic studies in mice. The core offers consultation and assistance with
experimental design, and an expanding list of services including Comprehensive Laboratory Animal Monitoring
System (CLAMS) that can simultaneously record energy expenditure, locomotor activity, eating and drinking,
glucose and insulin clamp studies (including radioactive tracers for determining hepatic glucose output and
uptake into other tissues), measurement of body composition using dual emission x-ray absorptiometry
(DEXA) and nuclear magnetic resonance spectroscopy, thermal imaging, exercise capacity, and a variety of
standard metabolic assays. In addition to the many existing services that have been critical to the productivity
of DRC investigators, we are excited to be providing new services aimed at phenotyping in variably controlled
conditions of ambient temperature and light, as well as facilitating metabolic flux studies through the
development of “cold clamp” techniques for delivery of isotope-labeled metabolites while controlling glucose
and insulin levels. Studies in the core are performed by two research specialists and a technical director under
the leadership of Dr. Joseph Baur and coordinated with other core laboratories including the Biomarkers and
Metabolomics cores. These efforts allow DRC investigators to rapidly translate ideas from the bench to mice as
the first critical steps toward new therapeutic approaches for the multitude of patients suffering form diabetes
and related disorders.

## Key facts

- **NIH application ID:** 10137222
- **Project number:** 5P30DK019525-45
- **Recipient organization:** UNIVERSITY OF PENNSYLVANIA
- **Principal Investigator:** Joseph A. Baur
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $216,777
- **Award type:** 5
- **Project period:** 1997-03-01 → 2022-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10137222

## Citation

> US National Institutes of Health, RePORTER application 10137222, Mouse Phenotyping, Physiology, and Metabolism Core (5P30DK019525-45). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10137222. Licensed CC0.

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