# Emerging Neuroviruses and Neurological Inflammatory Diseases

> **NIH NIH R01** · JOHNS HOPKINS UNIVERSITY · 2021 · $324,682

## Abstract

PROJECT SUMMARY
The recent outbreaks of arboviral infections such as Zika and Chikungunya in Latin American and Caribbean
countries have uncovered the role of emergent viral infections in the increased incidence of neuroinflammatory
disorders such as encephalitis, myelitis and Guillain-Barré syndrome (GBS). Here, we propose a multi-center
model of university-hospital sites in Colombia to facilitate clinical, epidemiological, and virological surveillance
and research of neurological disorders associated with emerging infections. The model already established as
the Neurovirus Emerging in the Americas Study (NEAS), will serve as an observatory of neurological disorders
associated with emerging viral infections and will facilitate the long-term goals of building and strengthening
sustainable research capacity in Colombia to address the emerging threat of viral illnesses and their
neurological complications. Based on our preliminary studies that helped to characterize clinical,
immunological and virological features of Zika-associated GBS in Colombia (Parra et al., NEJM 2016), we
hypothesize that acute neurological problems in the adult population of areas affected by emergent viral
infections result from complex host-viral interactions driven by previously established circulating arboviruses
(e.g., dengue, enteroviruses) as well as emergent pathogens (e.g., Zika and Chikungunya); and that variations
in viral genotype as well as host immunological responses to previous viral infections drive pathogenicity and
severity of neurological disease. To address this hypothesis, the specific aims of this proposal are: 1) To utilize
the NEAS model to establish a sustainable approach for assessment of acute neuroinflammatory disorders
such as GBS and encephalitis-myelitis and determine the role of emergent infections in the development of
such complications, 2) To implement state of the art technologies to improve the diagnosis of emerging
pathogens in the onset of acute neuroinflammatory disorders; and 3) To establish a training program to
enhance the competence of Colombian researchers in the use of next generation molecular and immunological
techniques, and computational biological approaches in metagenomics and pathogen discovery studies. We
will take advantage of the past and present experience with patient recruitment and biosample collection in the
NEAS cohort study population, the use of state-of-the-art immunological assays, next generation sequencing,
and massive multiplexed viral peptides assay (VirScan) to achieve such aims. We believe the findings of this
project will have a major public health impact and will address important questions related to viral diversity and
impact on disease severity, information needed for understanding disease pathogenesis, management and
vaccine development. This project will also contribute to building up capacity in Colombia by investing in
clinical and translational research to better characterize neurological comp...

## Key facts

- **NIH application ID:** 10137331
- **Project number:** 5R01NS110122-03
- **Recipient organization:** JOHNS HOPKINS UNIVERSITY
- **Principal Investigator:** CARLOS A PARDO-VILLAMIZAR
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $324,682
- **Award type:** 5
- **Project period:** 2019-07-15 → 2024-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10137331

## Citation

> US National Institutes of Health, RePORTER application 10137331, Emerging Neuroviruses and Neurological Inflammatory Diseases (5R01NS110122-03). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10137331. Licensed CC0.

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