# Functional Genomics and Bioinformatics Core Laboratory

> **NIH NIH P42** · UNIVERSITY OF WASHINGTON · 2021 · $318,884

## Abstract

PROJECT SUMMARY 
Research from many laboratories, including those of Superfund investigators, has established that chemical 
exposure of biological systems results in expression changes of numerous RNA and protein molecules and 
these changes are correlated with, and are indicative of toxicity. In addition, several molecular epidemiologic 
studies have identified correlations between genetic polymorphisms and incidence of environmental-related 
disease. Toxicological monitoring increasingly involves the assessment of genetic and other molecular 
measurements derived from individuals and sentinel animals, for the purpose of detecting possible markers of 
disease susceptibility, as well as identification of early indicators of chemical effect, such as alterations in gene 
expression profiles due to exposure to environmental toxicants. Various targeted molecular methods as well 
as OMICs based approaches have been developed in recent years and continue to develop rapidly. These 
methods complement each other and allow for mechanistic investigations of entire biological pathways and 
networks, as well as their individual components. The optimal application of these state-of-the-art 
methodologies requires considerable expertise in a) sample preparation and processing, b) generation and 
quality assessment of the data, c) rigorous statistical and bioinformatics analysis, d) as well as interpretation of 
the complex data sets. It would be very challenging and costly for UW SRP project investigators to acquire 
expertise in all of the aforementioned areas. The UW SRP FGBLC addresses this challenge. It provides 
leadership and expertise for genomics, transcriptomics, epigenetics and proteomics based methods, as well as 
a service facility for UW SRP investigators that supports the study of gene-environment interactions in the 
context of environmental health sciences research. The UW SRP FGBLC enables SRP investigators to utilize 
a wide range of molecular biology and bioinformatics related methodologies suited to perform mechanistic 
studies and to identify markers of exposure to toxicants, impaired physiologic and neurologic function, and 
susceptibility to neurotoxicity induced by environmental toxicants, particularly those that are commonly present 
at hazardous waste sites. The UW SRP FGBCL shared resource facility provides the aforementioned 
leadership and expertise, as well as a large range of genomics, transcriptomics and other molecular based 
assays in a cost-effective and efficient manner, thereby maximizing the availability of these resources for UW 
SRP investigators. Thus, the UW SRP FGBCL plays a crucial role in supporting the UW Superfund Research 
Program's mission to identify the interactions between genetic, epigenetic and environmental factors that 
contribute to neurotoxicity and other physiological impairment.

## Key facts

- **NIH application ID:** 10137956
- **Project number:** 5P42ES004696-33
- **Recipient organization:** UNIVERSITY OF WASHINGTON
- **Principal Investigator:** Theo K. Bammler
- **Activity code:** P42 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $318,884
- **Award type:** 5
- **Project period:** 1997-04-01 → 2023-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10137956

## Citation

> US National Institutes of Health, RePORTER application 10137956, Functional Genomics and Bioinformatics Core Laboratory (5P42ES004696-33). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10137956. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*