# FIT-PLESE: Tracking Lipids

> **NIH NIH R03** · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · 2021 · $72,500

## Abstract

Summary
The proposed analysis FIT-PLESE: Tracking Lipids utilizes serum and blood from obese
infertile women enrolled in the Reproductive Medicine Network trial FIT-PLESE who conceived
and carried their pregnancy and delivered. The objective is to determine what changes occur in
atherogenic apolipoproteins (small LDL particles, ApoB, LP [a], and omega acids) with
immediate pre-pregnancy diet and/or exercise with or without weight loss and if changes are
maintained during pregnancy. FIT-PLESE provided monitored exercise and/or prepared meals
with an over the counter weight loss medication to infertile obese women immediately prior to
ovulation induction with intrauterine insemination. For those who conceived, labs were drawn
pre and post intervention and at 16, 24 and 32 weeks of pregnancy. Mechanistically how do
apolipoproteins lipids specifically change with the intervention(s) and which changes are
essential with and without weight loss to fewer pregnancy complications? Specific pregnancy
complications preterm birth, SGA, LGA, diabetes, preeclampsia) with specific apolipoprotein,
responses will be associated. The long-term goal is to determine which specific atherogenic
apolipoprotein response is key. This secondary analysis of existing data is to obtain key
information as Pilot data. A larger subsequent R01 submission will follow. Pharmacological
and/or non-pharmacological therapies will now have specific targets for reduction leading to
better maternal/child outcomes. With respect to outcomes, we expect that understanding best
responses to the interventions will have short-term, long-term, and generational benefits.

## Key facts

- **NIH application ID:** 10137985
- **Project number:** 5R03HD101893-02
- **Recipient organization:** UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR
- **Principal Investigator:** ROBERT A WILD
- **Activity code:** R03 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $72,500
- **Award type:** 5
- **Project period:** 2020-04-03 → 2023-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10137985

## Citation

> US National Institutes of Health, RePORTER application 10137985, FIT-PLESE: Tracking Lipids (5R03HD101893-02). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10137985. Licensed CC0.

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