# Highly multiplexed live-cell GPCR arrays for drug discovery in glioma.

> **NIH NIH R41** · SPECTRAGENETICS · 2021 · $222,717

## Abstract

Project summary/Abstract
We will deploy an automated multiplexed live-cell assay to detect and quantify agonist
and inverse-agonist activities against 55 GPCRs known to be upregulated or
downregulated in human gliomas. The assay will be used to look for the secretion of
effectors for any of the 55 receptors by 48 established glioma cell lines of the Human
Glioblastoma Cell Culture Resource. This endeavor may yield new leads towards the
development of anti-tumor therapeutics, and will provide a platform for detecting such
leads in resected tumor tissue and in chemical or biologic libraries in future experiments.

## Key facts

- **NIH application ID:** 10139682
- **Project number:** 1R41CA257114-01
- **Recipient organization:** SPECTRAGENETICS
- **Principal Investigator:** JONATHAN W JARVIK
- **Activity code:** R41 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $222,717
- **Award type:** 1
- **Project period:** 2021-04-07 → 2022-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10139682

## Citation

> US National Institutes of Health, RePORTER application 10139682, Highly multiplexed live-cell GPCR arrays for drug discovery in glioma. (1R41CA257114-01). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10139682. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*