# Malaria Epidemiology In Southeast Asia: Intra- and Inter-Country Dynamics

> **NIH NIH U19** · UNIVERSITY OF SOUTH FLORIDA · 2021 · $318,004

## Abstract

PROJECT 1 SUMMARY
Despite the recent global reduction in malaria morbidity and mortality, malaria in the Greater Mekong
Subregion (GMS) of Southeast Asia remains one of the most important public health problems. While nations
in this region are moving towards malaria elimination, they face a daunting array of challenges, including
continuous transmission of malaria along the international borders, introduction and spread of multidrug
resistant malaria parasites by human migrants from neighboring countries, and the persistent Plasmodium
vivax malaria. Accordingly, we strategically select study sites at the international borders of China, Thailand
and Myanmar, which vary significantly in malaria endemicity, to address these problems. The overarching
objective of this project is to gain critical epidemiological information about factors contributing to the
persistence of border malaria in the GMS so that more effective malaria control strategies can be developed. In
this project, we aim to (1) conduct malaria surveillance and use highly sensitive molecular diagnostic tools to
identify transmission hotspots and risk factors for malaria infection; (2) determine and monitor the impact of
control programs and parasite introduction in the border regions on changes in parasite population diversity in
space and time using population genomic and landscape genetic tools; and 3) evaluate the effectiveness of the
chloroquine-primaquine treatment regimen as a radical cure of vivax malaria in border areas with high
prevalence of glucose-6-phosphate dehydrogenase deficiency. This project lays important foundations for
other projects of the ICEMR program, and will provide critical knowledge for developing and evaluating
integrated malaria management strategies.

## Key facts

- **NIH application ID:** 10140272
- **Project number:** 5U19AI089672-13
- **Recipient organization:** UNIVERSITY OF SOUTH FLORIDA
- **Principal Investigator:** Myat Phone Kyaw
- **Activity code:** U19 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $318,004
- **Award type:** 5
- **Project period:** 2010-07-01 → 2024-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10140272

## Citation

> US National Institutes of Health, RePORTER application 10140272, Malaria Epidemiology In Southeast Asia: Intra- and Inter-Country Dynamics (5U19AI089672-13). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10140272. Licensed CC0.

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