# Biostatistics and Bioinformatics Facility Core

> **NIH NIH P30** · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · 2021 · $208,485

## Abstract

Project Summary
The mission of Mount Sinai's Transdisciplinary P30 Center on Early Environmental Exposures is to accelerate
team science based research utilizing life course–informed models of health. The Biostatistics and
Bioinformatics Facility Core (BBFC) plays a key role in that mission by modeling complex, sometimes novel,
exposure and phenotype data generated by center members across a wide variety of study types (basic,
clinical, epidemiologic) while focusing on developing methods to better address our Center's research themes
(multiple exposures/mixtures, stress-chemical interactions, and sex specific effects of environmental
exposure). The data structures we emphasize in this Center are multi-dimensional and complex—not simple,
single exposures related to a single health outcome. While we offer standard data analytic services (e.g., linear
models, longitudinal mixed effects models, power calculations, study analysis planning) the statistical methods
and study designs needed for analyzing the complex, high-dimensional data that arise in much of our Center's
work are still relatively new and require knowledge of advanced statistical techniques and the ability to curate
and interpret complex biologic data – expertise maintained by the faculty of the BBFC. Core faculty and
researchers engage in research motivated by questions and methodological challenges that arise from center
collaborations and innovations by our Center Cores. For example, our Center's unique core facility services,
such as the tooth biomarker that reconstruct past chemical exposure (described in the Integrated Health
Sciences Facility Core) and the operant test chamber for multiple domains of executive functioning (detailed in
the Phenotyping and Environmental Modifiers Facility Core) generated the need to create novel data analytical
approaches that harness the full potential of these innovative measures. Core faculty and staff provide
statistical and bioinformatics training for postdoctoral fellows working on environmental health sciences (EHS)
related projects. Providing such services via a core facility allows the P30 Center to build and maintain
specialized resources (e.g., expertise in measuring and advanced statistical methods related to evaluation of
environmental mixtures). Thus, to support the overall goals of the P30 Center, the BBFC proposes the
following specific aims: (1) to ensure that Center projects are grounded in sound biostatistical/bioinformatics
principles and use state-of-the-art methods for design and analysis of EHS data; (2) to conduct mission-related
biostatistical/bioinformatics methods research for further quality assurance of all research and data analysis
methods; and (3) to assist in the training of biostatistical/bioinformatics principles and analysis methods to
Center investigators, fellows and post-doctoral trainees.

## Key facts

- **NIH application ID:** 10140357
- **Project number:** 5P30ES023515-08
- **Recipient organization:** ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
- **Principal Investigator:** Chris Gennings
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $208,485
- **Award type:** 5
- **Project period:** 2014-06-18 → 2023-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10140357

## Citation

> US National Institutes of Health, RePORTER application 10140357, Biostatistics and Bioinformatics Facility Core (5P30ES023515-08). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10140357. Licensed CC0.

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