# Reducing the Burden of Hepatocellular Carcinoma Among Migrant Populations: Improving prevention and outcomes through disease modeling

> **NIH NIH F30** · MAYO CLINIC ROCHESTER · 2021 · $46,236

## Abstract

Project Summary
Hepatocellular carcinoma (HCC) is the fastest growing cause of cancer mortality in the United States. HCC is
preventable, and it disproportionately affects migrants with unrecognized asymptomatic Chronic Viral Hepatitis
(CVH). The long-term goal of this project is to reduce the occurrence of preventable liver cancer in migrant
populations. The overall objective of this proposal is to estimate the Chronic Viral Hepatitis (CVH) and
Hepatocellular Carcinoma (HCC) prevalence among migrants, to detect key identifiers associated with high-
burden groups, and to describe the comorbidities and outcomes of those groups. The purpose of achieving this
goal is to reduce the occurrence of preventable liver cancer in migrant populations. This study will contribute to
this through the generation of the epidemiological data required for patients, practitioners, and policymakers
alike to more readily identify the migrant groups that would benefit most from strategic screening and
surveillance.
The central hypothesis is that HCC and CVH risk and outcomes among migrants can be estimated by
demographics. This will be tested by pursuing two specific aims: 1) Establish prevalence of CVH and HCC
among migrant populations; and 2) Identify CVH and HCC comorbidities and outcomes within the migrant
population. Under the first aim, a proven CVH and HCC disease model will be paired with migrant population
statistics to establish the risk profiles for distinct migrant populations, including age group and country-of-origin.
Under the second aim, an existing retrospective, population-wide health dataset will be utilized to identify
common concomitant disease and outcomes among distinct migrant populations. The proposed research is
innovative because it focuses on identifying key characteristics unique to specific migrant populations and
establishing the associated CVH and HCC risk profiles. If achieved, the results are expected to be significant
because they will contribute to resolving the current knowledge gaps in the disease burden and disparities of
distinct migrant populations, allowing for risk stratifying and appropriate modifications to impact screening
policy and practice.

## Key facts

- **NIH application ID:** 10140558
- **Project number:** 1F30CA257228-01
- **Recipient organization:** MAYO CLINIC ROCHESTER
- **Principal Investigator:** Kenneth Andrew Valles
- **Activity code:** F30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $46,236
- **Award type:** 1
- **Project period:** 2021-02-01 → 2025-01-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10140558

## Citation

> US National Institutes of Health, RePORTER application 10140558, Reducing the Burden of Hepatocellular Carcinoma Among Migrant Populations: Improving prevention and outcomes through disease modeling (1F30CA257228-01). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10140558. Licensed CC0.

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