# Functional and dysfunctional human CD4 T cell and B cell responses to bacteria and viruses

> **NIH NIH U19** · LA JOLLA INSTITUTE FOR IMMUNOLOGY · 2020 · $982,950

## Abstract

PROJECT SUMMARY
Overall Component
COVID19 is a severe ongoing pandemic. Our understanding of the immune response to this disease is lacking,
which impairs both the development of proper therapeutics and a vaccine. Vaccines are one of the most cost
effective and extraordinarily successful medical interventions. Most of those vaccines depend on CD4 T+ cells
and their help to B cells. We have developed multiple new techniques to study human CD4+ T cells over the past
several years, which have have been implementing in our LJI CCHI. The supplement proposed here will facilitate
rapid and vigorous pursuit of an understanding of the T cell responses to SARS-CoV2 in humans, which may
help in the development of treatments and vaccines for COVID19.

## Key facts

- **NIH application ID:** 10140622
- **Project number:** 3U19AI142742-02S1
- **Recipient organization:** LA JOLLA INSTITUTE FOR IMMUNOLOGY
- **Principal Investigator:** Shane P Crotty
- **Activity code:** U19 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $982,950
- **Award type:** 3
- **Project period:** 2020-05-26 → 2021-02-28

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10140622

## Citation

> US National Institutes of Health, RePORTER application 10140622, Functional and dysfunctional human CD4 T cell and B cell responses to bacteria and viruses (3U19AI142742-02S1). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10140622. Licensed CC0.

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