# Administrative supplement to The human amygdala in social processing: circuits, physiology, behavior, and neuromodulation

> **NIH NIH K01** · BAYLOR COLLEGE OF MEDICINE · 2020 · $54,000

## Abstract

SUMMARY:
The purpose of the current proposal is to enable the PI to transition to independent research investigator, with expertise
in electrophysiological analysis techniques to examine the real-time function of the emotional (affective) system. The
proposed training plan includes structured mentoring, hands-on training in electrophysiology and bioinformatics,
didactic coursework, and a rigorous proposed research study. The proposed experiments leverage a highly specialized
experimental setting: human epilepsy patients with depth electrodes implanted in the amygdala – central to social and
emotion processing – for routine seizure focus monitoring in medically refractory epilepsy. In this setting, we can record
local neuronal activity as well as apply small electrical currents to stimulate for research purposes. The proposed training
in electrophysiology will enable the PI to examine the real-time function of the amygdala, which, when paired with her
existing expertise in human neuroimaging and psychiatric behavioral measurement, will allow a thorough comparison of
amygdala connectivity and dynamics across patients with a wide range of social processing abilities. This project
examines the hypothesis that the amygdala plays a direct and causal role in social processing.
Within the NIMH RDoC Framework, the current proposal examines the role of the amygdala in the Domain of Social
Processes, including the Construct of Social Communication and the Construct of Perception and Understanding of
Others. We will examine these functions from the level of neural circuits, physiology, and behavior, and to examine the
potential for amygdala neuromodulation to enhance social processing. Deeper understanding of the neural circuitry of
social processing will facilitate the study and treatment of depressive disorders with implications for broader
neuropsychiatric conditions as well. Results of this project will provide pilot data for an NIMH R01 application, and
compliment the ongoing work of the applicant and the mentorship team. Coursework will include didactic, and hands-on
training in electrophysiological analysis, didactic training in advanced statistical modeling to build upon the applicant’s
current training in biostatistics and clinical trials design, and continued training in research ethics. Therefore, this award
would allow the PI to accomplish her goal of becoming an independent, academic research investigator, while advancing
the research objective of evaluating the causal role of the amygdala in social processing.

## Key facts

- **NIH application ID:** 10140757
- **Project number:** 3K01MH116364-03S1
- **Recipient organization:** BAYLOR COLLEGE OF MEDICINE
- **Principal Investigator:** Kelly Rowe Bijanki
- **Activity code:** K01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $54,000
- **Award type:** 3
- **Project period:** 2019-09-01 → 2022-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10140757

## Citation

> US National Institutes of Health, RePORTER application 10140757, Administrative supplement to The human amygdala in social processing: circuits, physiology, behavior, and neuromodulation (3K01MH116364-03S1). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10140757. Licensed CC0.

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