# Comprehensive Biology: Exploiting the Yeast Genome

> **NIH NIH P41** · UNIVERSITY OF WASHINGTON · 2021 · $1,850,727

## Abstract

Project Summary
Since its inception, the Yeast Resource Center has focused on understanding how genome sequence relates
to protein function. The Center began just as budding yeast became the first eukaryote to have its genome
sequence completed, and we proposed to use an array of technologies to interpret this sequence. In this
application, we undertake novel challenges, centered on understanding how variation in proteins affects their
levels, modification, function and structure. We will develop new technologies in three areas: 1) Perturbing and
sensing changes to complex pathways; 2) Protein detection and quantitation by mass spectrometry; and 3)
Higher order protein structure. These technologies will be driven by ten closely integrated Driving Biomedical
Projects. Yeast remains an unparalleled experimental system to develop, test and refine these technologies.
As the technologies mature, we will extend their application to higher eukaryotes through internal projects and
external collaborations. Furthermore, we make our technologies available as they become robust, through
broad collaboration and a well-established track record of dissemination and training.

## Key facts

- **NIH application ID:** 10141243
- **Project number:** 5P41GM103533-25
- **Recipient organization:** UNIVERSITY OF WASHINGTON
- **Principal Investigator:** Michael MacCoss
- **Activity code:** P41 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $1,850,727
- **Award type:** 5
- **Project period:** 1997-09-30 → 2022-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10141243

## Citation

> US National Institutes of Health, RePORTER application 10141243, Comprehensive Biology: Exploiting the Yeast Genome (5P41GM103533-25). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10141243. Licensed CC0.

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