# CWRU Site for HEAL: Longitudinal Initiative in Opioid Exposed Newborns

> **NIH NIH RL1** · CASE WESTERN RESERVE UNIVERSITY · 2020 · $1

## Abstract

Neonatal Opioid Withdrawal Syndrome (NOWS) is a major public health problem, as the
incidence of NOWS in the USA has increased five-fold since 2000-2012 to almost 6 per
1000 hospital births, with an increase in health care expenditures from $200 million to
$1.5 billion. Current critical knowledge gaps in the field are the impact of antenatal
opioid exposure and NOWS on childhood brain structure and connectivity and on
medical, developmental, and behavioral trajectories in early childhood. It is also
unknown how these effects are modulated by associated maternal, neonatal, and
environmental factors, and how the home environment, maternal mental health, and
parenting styles modify such trajectories of brain connectivity and neurodevelopment at
key developmental windows.
This proposal in response to the HEAL Initiative: Antenatal Opioid Exposure
Longitudinal Study Consortium leverages the established infrastructure and longstanding
collaborations of four of the highest enrolling clinical sites and data
coordinating center of the Eunice Kennedy Shriver NICHD Neonatal Research Network
(NRN) to address these knowledge gaps. We term our proposal the Outcomes of
Babies with Opioid Exposure (OBOE study). Systematic and in-depth study of a well
characterized observational cohort using validated and sophisticated clinical and
neuroimaging measures will improve understanding of the structural and functional
sequelae resulting from prenatal opioid exposure and NOWs, and their interactions with
the maternal-infant dyad. Such data will identify modifiable risk factors and suggest
potentially better treatment strategies, including differences in outcomes with
modification of specific environmental factors, or pharmacotherapy.

## Key facts

- **NIH application ID:** 10141400
- **Project number:** 1RL1HD104253-01
- **Recipient organization:** CASE WESTERN RESERVE UNIVERSITY
- **Principal Investigator:** DEANNE E WILSON-COSTELLO
- **Activity code:** RL1 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $1
- **Award type:** 1
- **Project period:** 2019-10-01 → 2024-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10141400

## Citation

> US National Institutes of Health, RePORTER application 10141400, CWRU Site for HEAL: Longitudinal Initiative in Opioid Exposed Newborns (1RL1HD104253-01). Retrieved via AI Analytics 2026-06-24 from https://api.ai-analytics.org/grant/nih/10141400. Licensed CC0.

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