# Enhancing access to multi-omic data assets in the AMP-AD research ecosystem

> **NIH NIH U24** · SAGE BIONETWORKS · 2020 · $1,020,000

## Abstract

Project Summary/Abstract
Alzheimer’s Disease (AD) is a debilitating neurodegenerative disease affecting more than 5 million Americans.
Despite significant investment in drug discovery and development, no therapeutic options yet exist that can
prevent, slow, or cure AD. The Accelerating Medicines Partnership in Alzheimer’s Disease Target Discovery
and Preclinical Validation project (AMP-AD) was designed to help address this problem by identifying
candidate targets through evaluation of AD-induced changes in human molecular state on a systems level. The
AMP-AD Data Coordination Center (DCC) manages and distributes AMP-AD data assets in accordance with
the FAIR principles in order to support the open science principles of the AMP-AD program. Data assets are
distributed through the AD Knowledge Portal, an NIH-designated repository that serves to support the NIA’s
strategic goal to propagate data sharing under FAIR principles and to promote open science. This supplement
is designed to extend the functionality of the DCC to meet the emerging needs and opportunities enabled by
recent expansions in the scale and scope of the AMP-AD data ecosystem including through the initiation of
AMP-AD 2.0. The supplement will extend the scale of the data ecosystem by increasing data ingress capacity
to support data contributors in rapid data annotation, validation and upload. It will also ensure interoperability
between high value AMP-AD data assets, particularly between AMP-AD 1.0 and 2.0, by ensuring that they are
harmoniously processed to meet current analysis standards.

## Key facts

- **NIH application ID:** 10141466
- **Project number:** 3U24AG061340-03S1
- **Recipient organization:** SAGE BIONETWORKS
- **Principal Investigator:** LARA M MANGRAVITE
- **Activity code:** U24 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $1,020,000
- **Award type:** 3
- **Project period:** 2018-09-30 → 2023-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10141466

## Citation

> US National Institutes of Health, RePORTER application 10141466, Enhancing access to multi-omic data assets in the AMP-AD research ecosystem (3U24AG061340-03S1). Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/grant/nih/10141466. Licensed CC0.

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