# COVID19 Admin Supplement to Rapidly Translate Immunobiology for Patient Benefit

> **NIH NIH R01** · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2020 · $312,232

## Abstract

PROJECT SUMMARY
This is an administrative supplement to the parent R01 AI052116 “SPATIOTEMPORAL CONTROL OF T CELL
SYNAPSE STABILIZATION AND SIGNALING” which for my entire career has been my central grant for
studies of T cell interactions leading to tolerance or activation. Here, we apply our considerable immune and
tissue-immune experience towards generating and exploiting a RapidPath platform to find rapid actionable
immunotherapeutic targets for COVID-19 patients for limiting damage due to SARS-CoV-2 infections.
In aim 1 of this study, we will build a lung plus virus plus immune platform in which the role of specific T cells of
different activation status –alone and through their modulation of myeloids cells—will be assessed in the
response of damage to lung epithelium plus/minus endothelium (organoid, with Roose/Gordon and lung slice
with Looney). This supplement will interact intensely with parallel studies of those labs and also with ongoing
studies that will also leverage RapidPath but are not in this first cohort of applications. This will provide `best in
class' model systems in human biology and will leverage our collective expertise. In aim 2 of this study, we
will test a panel of immunomodulatory drugs to determine if acute exposure to them can modulate lung
damage, likely through modulating myeloid biology. The net result will be validated immunotherapeutic
paths in robust pre-clinical human systems that recapitulate key features of COVID-19.

## Key facts

- **NIH application ID:** 10142156
- **Project number:** 3R01AI052116-18S1
- **Recipient organization:** UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
- **Principal Investigator:** MATTHEW F KRUMMEL
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $312,232
- **Award type:** 3
- **Project period:** 2020-05-27 → 2021-12-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10142156

## Citation

> US National Institutes of Health, RePORTER application 10142156, COVID19 Admin Supplement to Rapidly Translate Immunobiology for Patient Benefit (3R01AI052116-18S1). Retrieved via AI Analytics 2026-05-27 from https://api.ai-analytics.org/grant/nih/10142156. Licensed CC0.

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