# Clinical Sample Collection COVID19 Patients to Align with NIAID National Study

> **NIH NIH R01** · INSTITUTE FOR SYSTEMS BIOLOGY · 2020 · $441,482

## Abstract

Project Summary
The NIAID national protocol intends to enroll at least 1000 COVID19 patients in a study designed to track infected
patients through tracking, over time, their immune responses, viral load, and a variety of multi-omic analytes that
can provide deep insights into how infection by SARS-CoV-2 is revealed in host defense responses and disease-
perturbed networks. At the heart of this study is the establishment of high quality biorepositories that can be
used to quantitatively assess viral load, quantitatively interrogate viable PBMCs, and permit direct comparisons
between different patients and different time points of disease progression. The nature of the infection, with
highly differential patient outcomes, will eventually require significant computational efforts that can account for
confounding factors such as co-morbidities, the influence of various therapies that are being broadly tested in
these patients, etc. It will also almost certainly require all 1000 projected patients, if not more, to resolve some
of the most outstanding and urgent clinical questions. However, all of these results rely on establishing high
quality biobanks, resource sharing, and data sharing. This is an area in which the ISB has deep expertise and
is excited to contribute. The ISB and SMC launched a joint study designed to enroll 200 COVID19 patients
around 3/20/2020. That study has overlap with the NIAID protocol and shares a common set of over-arching
goals. Here we propose to increase that overlap and to make that accruing biobank of COVID19 patient
specimens and associated characterization data a national resource through inclusion in the NIAID protocol.

## Key facts

- **NIH application ID:** 10142303
- **Project number:** 3R01AI141953-02S1
- **Recipient organization:** INSTITUTE FOR SYSTEMS BIOLOGY
- **Principal Investigator:** Nitin S Baliga
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $441,482
- **Award type:** 3
- **Project period:** 2020-06-01 → 2022-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10142303

## Citation

> US National Institutes of Health, RePORTER application 10142303, Clinical Sample Collection COVID19 Patients to Align with NIAID National Study (3R01AI141953-02S1). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10142303. Licensed CC0.

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