# Core D: Neuropathology Core

> **NIH NIH P30** · JOHNS HOPKINS UNIVERSITY · 2021 · $596,366

## Abstract

NEUROPATHOLOGY CORE – CORE D: PROJECT SUMMARY/ABSTRACT
Postmortem examination remains critical to elucidate the etiology in cases of dementia and to confirm the
diagnosis of AD, despite recent advances in neuroimaging and fluid biomarkers. Autopsy is also critical for
confirming the clinical diagnosis and identifying comorbidities, which are common in older subjects. The
Neuropathology Core (Core D) of the Johns Hopkins Alzheimer's Disease Research Center (JHADRC) has
three overarching goals. The first is to conduct postmortem neuropathological assessments in subjects
enrolled in the JHADRC Clinical Core. Second, to prepare, store, and distribute autopsy brain tissues for
research. The third goal is the training of young physicians and neuroscientists in the neuropathology of
dementias and neurodegenerative diseases. The specific aims of Core D are as follows: (1) to arrange and
perform autopsies on clinically well-characterized subjects enrolled through the JHADRC and assist with
consensus diagnoses on JHADRC subjects, (2) to store optimally prepared tissues from the autopsies and to
make these specimens available to investigators associated with the JHADRC and at other collaborating
institutions, (3) to integrate the neuropathologic data from these cases with the clinical and biomarker data
acquired in the same participants, using the JHADRC database, and to submit the neuropathology data to the
National Alzheimer's Coordinating Center (NACC), working with the Data Core (4) to support the assessment
of genetically engineered mouse models relevant to Alzheimer's disease (AD) and related disorders, and (5) to
train basic investigators and clinical neuroscientists in the morphological and diagnostic concepts relevant to
AD, to other types of dementias and neurodegenerative disorders (including trainees supported by the REC).
In addition, the availability of human brain postmortem tissues has become increasingly important for validating
research hypotheses and for investigations and development of biomarkers of AD. Core D will therefore be
expanding its postmortem tissue collection to include a large number of specimens from younger subjects (30
to 65 years) suitable to examine the very early stages of AD pathology and its pathogenesis.

## Key facts

- **NIH application ID:** 10142347
- **Project number:** 5P30AG066507-02
- **Recipient organization:** JOHNS HOPKINS UNIVERSITY
- **Principal Investigator:** JUAN TRONCOSO
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $596,366
- **Award type:** 5
- **Project period:** 2020-04-15 → 2025-02-28

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10142347

## Citation

> US National Institutes of Health, RePORTER application 10142347, Core D: Neuropathology Core (5P30AG066507-02). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10142347. Licensed CC0.

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