# Mouse Phenome Project

> **NIH NIH R01** · JACKSON LABORATORY · 2021 · $592,180

## Abstract

PROJECT SUMMARY
The goal of the Mouse Phenome Project is to support biomedical research by delivering a widely-accessed
and highly functional data repository for well-documented disease relevant phenotypic data from
heterogeneous mouse populations. Human studies of complex traits have revealed genetic loci that are
involved in disease and other conditions. However, it is becoming increasingly clear that prohibitively large
sample sizes are required to identify genome-wide significant variants. Studying model organisms can provide
insight, aid in prioritization, and facilitate translation of research findings into practice. To be truly effective in
using model organism studies in the interpretation of human disease, it is essential that data be available to
end-user biologists and computational scientists in a useable form that assures quality, interpretability and
validity. These needs are best captured under the FAIR (Findable, Accessible, Interoperable and Reuseable)
data standard. We will advance the Mouse Phenome Database (MPD) in response to emerging needs of the
research community to annotate data, make it available through a FAIR-compliant public repository, and
provide tools that enable users to visualize, analyze, and download primary and summary data. We propose to
optimize our development to address problems of cross-species and cross-population data integration and
analysis. Our objectives are to provide a central repository for data, documentation, and protocols, offering a
unique and important venue for investigators needing to make their data public; to continually refine and
develop tools and features to best locate, present, and analyze those datasets; and to maintain, enhance, and
promote this resource to further enable quantitative, standardized and predictive phenotype studies and, in turn
facilitate new scientific advances. We will achieve these objectives in three Specific Aims. Aim 1: We will
expand the data repository with extensive complex trait data and upgrade the MPD system to provide a
persistent, FAIR compliant, public repository for primary mouse phenotypic data. Aim 2: We will enhance the
MPD tool set to enable multivariate biostatistical and statistical genetics analysis along with cross-species and
cross-population data integration and analysis. Aim 3: We will provide essential documentation, and ensure
outreach, education, and training opportunities. Impact: The proposed efforts will help maximize the value of
these data and provide the traceability and scientific rigor required for extension and translation. Completion of
the proposed work will result in a powerful, interoperable system for public access to and analysis of mouse
phenotype data and will ultimately provide researchers a seamless experience for the extrapolation of model
organism genetics data to human genetic variation.

## Key facts

- **NIH application ID:** 10142396
- **Project number:** 5R01DA028420-17
- **Recipient organization:** JACKSON LABORATORY
- **Principal Investigator:** MOLLY A BOGUE
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $592,180
- **Award type:** 5
- **Project period:** 2004-07-01 → 2025-02-28

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10142396

## Citation

> US National Institutes of Health, RePORTER application 10142396, Mouse Phenome Project (5R01DA028420-17). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10142396. Licensed CC0.

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