Community Engagement (CE). The CCTSI places a high priority on engaging community members and other stakeholders in the full spectrum of clinical and translational research (CTR). The Community Engagement and Research (CE&R) Core will include a portfolio of innovative programs and relationships including a nationally recognized Pilot Grant Program. The Core has demonstrated the value and benefits of engaging patients and communities as active partners in research to address community priorities, design studies in a culturally-sensitive and participant-friendly structure, implement and disseminate findings into the community, and enhance public trust and participation in research. The CE&R Core will broaden the stakeholders with whom it engages and further integrate CE&R throughout the CCTSI, increase the bi-directional nature of its work, and integrate engagement work with that of its partners in team science at the University of Colorado (CU), Colorado State University (CSU), hospital partners, and the CTSA Consortium. To achieve these goals, the following Specific Aims are proposed: Aim 1: Expand the community stakeholders to include an array of healthcare organizations and payers to expand the potential for implementation and dissemination. Aim 2: Further infuse Community Engagement throughout the translational spectrum within all CCTSI programs and operations. Aim 3: Increase capacity for bi-directional engagement between researchers and community stakeholders to enhance the science of community engaged translational research. Collaboration and Multidisciplinary Team Science. The CCTSI has invested in the advancement of team science through incentives (e.g., leadership training in team science, team science pilot grant awards) that bring together investigators across different scientific disciplines and across different levels of the translational research spectrum to conduct innovative CTR. This Core will enhance and expand these programs by advancing the integration of community stakeholders in CTR research teams and by building a new Science of Team Science (SciTS) program. The SciTS program will be scaled up from activities first developed and evaluated at CSU. The overarching goals are to foster an environment that values team science research and to develop and evaluate evidence-based research team-building activities that enhance the success of research teams through the following Specific Aims: Aim 4: Catalyze translational collaboration and team science training and the engagement of community stakeholders with research teams. Aim 5: Implement a SciTS academic program to enhance the science and success of multidisciplinary research teams.