# Conduct of five day high throughput transcriptomic dose response studies of selected chemicals for the NTP

> **NIH NIH N01** · BATTELLE MEMORIAL INSTITUTE · 2020 · $355,608

## Abstract

These studies are being conducted to evaluate the hypothesis that benchmark dose/benchmark dose level (BMD/BMDL) analyses of transcriptional changes in the adult rat liver following short term oral exposure to a chemical will produce similar (if not slightly lower) points of departure compared to BMD/BMDL analyses of apical end-points and to evaluate reproducibility of the approach. This approach may be useful in comparing classes of compounds and providing quantitative data to inform risk assessments.
Keywords: toxicity, high throughput transcriptomics, cancer genomics

## Key facts

- **NIH application ID:** 10143133
- **Project number:** 273201400015C-P00017-9999-16
- **Recipient organization:** BATTELLE MEMORIAL INSTITUTE
- **Principal Investigator:** BARNEY SPARROW
- **Activity code:** N01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $355,608
- **Award type:** —
- **Project period:** 2014-04-15 → 2021-04-14

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10143133

## Citation

> US National Institutes of Health, RePORTER application 10143133, Conduct of five day high throughput transcriptomic dose response studies of selected chemicals for the NTP (273201400015C-P00017-9999-16). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10143133. Licensed CC0.

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