# Role of ATG14 in the regulation of hepatic function

> **NIH NIH R01** · INDIANA UNIVERSITY INDIANAPOLIS · 2021 · $441,299

## Abstract

Project Summary
 Nonalcoholic fatty liver disease (NAFLD) affects over 30% adults in the US. The NAFLD initially manifests
as hepatic steatosis and progresses to nonalcoholic steatohepatitis (NASH), fibrosis, and even cirrhosis or
hepatocellular carcinoma. Due to the progressive nature of the disease, it is crucial to understand the early
pathogenic events of the NAFLD development. Among those early events, abnormal lipid metabolism is largely
responsible for the hepatic steatosis that is manifested as extra triglyceride accumulation in the liver in the form
of lipid droplets. Triglyceride homeostasis is a very dynamic process as it involves both biosynthesis and
breakdown. The lipid droplet mobilization remains poorly understood. In this application, the research team will
investigate the regulatory mechanisms of lipid droplet breakdown in cellular and animal models with a focus on
a key autophagy regulator – autophagy related 14. It is expected that the proposed research will provide key
mechanistic insights into the strategy for therapeutic intervention and treatment of NAFLD.

## Key facts

- **NIH application ID:** 10143232
- **Project number:** 5R01DK120689-02
- **Recipient organization:** INDIANA UNIVERSITY INDIANAPOLIS
- **Principal Investigator:** X. Charlie Dong
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $441,299
- **Award type:** 5
- **Project period:** 2020-06-01 → 2024-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10143232

## Citation

> US National Institutes of Health, RePORTER application 10143232, Role of ATG14 in the regulation of hepatic function (5R01DK120689-02). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10143232. Licensed CC0.

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