# IMmunoPhenotyping Assessment of a Covid-19 Cohort (IMPACC): Clinical Site

> **NIH NIH U19** · BOSTON CHILDREN'S HOSPITAL · 2020 · $184,957

## Abstract

PROJECT SUMMARY:
From a cluster of respiratory illnesses in Wuhan, China, to a worldwide pandemic, the world has learned of a
novel coronavirus (SARS-CoV-2) but little is known about the pathogenesis that leads to the disease termed
“COVID”. Patients with SARS-CoV-2 infection range from asymptomatic, mild, moderate, to severe infections,
resulting in ICU hospitalization and even death. In the US alone, there is a prediction of ~100,000 – 240,000
deaths from SARS-CoV-2 infections. There is an urgent need to immunophenotype patients with COVID to
define biomarkers of disease severity and outcome to inform new interventions to prevent or treat this deadly
disease.
 Key to characterizing the human immune response to SARS-CoV-2, is recruitment , enrollment and
retention of a cohort of study participants with COVID. To this end, we will employ best practices in clinical
research to pursue three Specific Aims (SAs). In SA1, we will recruit and enroll a well-defined cohort of adults
with SARS-CoV-2 (COVID-19); in SA2, we will obtain and store biosamples from patients in this COVID-19
cohort in support the NIAID immunophenotyping effort and in SA3 we will partner with the Clinical & Data
Coordinating Center (CDCC) to provide clinical data from this COVID-19 cohort to ensure these samples are
highly annotated with key clinical data.
Overall, successful pursuit of these SAs will provide well defined clinical samples and high quality
clinical data to support the NIAID COVID immunophenotyping effort.

## Key facts

- **NIH application ID:** 10143563
- **Project number:** 3U19AI118608-04S2
- **Recipient organization:** BOSTON CHILDREN'S HOSPITAL
- **Principal Investigator:** OFER LEVY
- **Activity code:** U19 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $184,957
- **Award type:** 3
- **Project period:** 2020-05-08 → 2021-11-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10143563

## Citation

> US National Institutes of Health, RePORTER application 10143563, IMmunoPhenotyping Assessment of a Covid-19 Cohort (IMPACC): Clinical Site (3U19AI118608-04S2). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10143563. Licensed CC0.

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