# Nonhuman Primate Reagent Resource

> **NIH NIH U24** · UNIV OF MASSACHUSETTS MED SCH WORCESTER · 2020 · $353,732

## Abstract

U24 AI126683 – Parent Award Abstract
Nonhuman primates (NHPs) serve a crucial role in translational research as animal models for exploring the
pathogenesis of infectious and noninfectious diseases, and for testing of biologic therapies and vaccines. While
many human diagnostic immunologic reagents cross react with the primate species commonly employed in
translational research, gaps exist for a substantial number of reagent targets. Furthermore, antibodies that
target specific immune functions or deplete specific lymphocyte subpopulations in vivo have proven valuable in
defining disease mechanisms or can be used as proof-of-concept for new therapies.
For the past 15 years, the NIH Nonhuman Primate Reagent Resource has responded to needs of the scientific
community by developing, manufacturing and distributing NHP-specific reagents for in vitro diagnostics and for
in vivo use. Utilization of this resource has grown dramatically since this program’s inception. During the last
budget year, we fulfilled 500 reagent requests from 126 investigators and distributed over 300 grams of
recombinant antibody for administration to NHPs.
Taking advantage of scientific advances and technological improvements in antibody development, engineering,
expression and vectoring, we will continue to support the scientific community utilizing NHP models across all
scientific disciplines.

## Key facts

- **NIH application ID:** 10143889
- **Project number:** 3U24AI126683-05S1
- **Recipient organization:** UNIV OF MASSACHUSETTS MED SCH WORCESTER
- **Principal Investigator:** Kathleen Engelman
- **Activity code:** U24 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $353,732
- **Award type:** 3
- **Project period:** 2020-06-01 → 2021-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10143889

## Citation

> US National Institutes of Health, RePORTER application 10143889, Nonhuman Primate Reagent Resource (3U24AI126683-05S1). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10143889. Licensed CC0.

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