# Single-Frame X-ray Tomosynthesis

> **NIH NIH R21** · MAYO CLINIC ROCHESTER · 2020 · $184,298

## Abstract

Abstract
We have developed a novel single-frame x-ray tomosynthesis (SFXT) imaging architecture that can produce 30
tomosynthesis volumes per second. Compared to conventional tomosynthesis, SFXT has a reduced field of view
and projection count but 10 to 100 times higher temporal resolution. This dramatic increase in speed has the
potential to open new clinical applications. The device utilizes standard components and is simple in design
compared to CT or MRI. We will build a prototype system, image both stationary and moving phantoms, and
conduct a pilot study to image swine during normal respiratory and cardiac motion. We will further evaluate the
utilization of SFXT in two specific applications. First, in radiation oncology, SFXT could guide the treatment of
lung stereotactic body radiation therapy (SBRT). By providing real-time feedback of the lung tumor location,
SFXT could enable safer ablation of central lung tumors with reduced incidence of radiation pneumonitis or
damage to the central airways, great vessels, or esophagus. Second, in the detection of cardiovascular disease,
SFXT could visualize calcium deposits in the coronary arteries. This has previously been achieved using CT, but
SFXT would provide the cost and radiation exposure profile necessary for calcium scoring to become a routine
tool in the personalized management of cardiovascular health. Still other, undiscovered applications may be
enabled by the high temporal resolution of SFXT.

## Key facts

- **NIH application ID:** 10143918
- **Project number:** 7R21EB026780-03
- **Recipient organization:** MAYO CLINIC ROCHESTER
- **Principal Investigator:** Scott Sigao Hsieh
- **Activity code:** R21 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $184,298
- **Award type:** 7
- **Project period:** 2018-08-15 → 2023-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10143918

## Citation

> US National Institutes of Health, RePORTER application 10143918, Single-Frame X-ray Tomosynthesis (7R21EB026780-03). Retrieved via AI Analytics 2026-05-28 from https://api.ai-analytics.org/grant/nih/10143918. Licensed CC0.

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