# Prognostic calculators for patients with Alzheimers disease and related dementias

> **NIH NIH R01** · NORTHERN CALIFORNIA INSTITUTE/RES/EDU · 2021 · $383,250

## Abstract

Abstract:
Considering prognosis and life expectancy in patients across all stages of Alzheimer's disease and related
dementias improves decision-making. Decisions that are highly influenced by prognosis for older adults with
Alzheimer's disease and related dementias include cancer screening, planning financially for nursing home
placement, and hospice eligibility. Despite the importance of prognosis, there are no widely-applicable,
accurate, and validated tools to estimate prognosis across all stages of Alzheimer's disease and related
dementias for patients living in the community. Existing models are either exclusively for persons with
advanced dementia in nursing homes, outdated, or suffer from small size or non-generalizable samples. Our
goal is to develop a set of clinically useful prognostic models specifically for persons with Alzheimer's disease
and related dementias. To maximize the likelihood that these models are accessible to busy clinicians, we will
embed these models on eprognosis.org, our online compendium of prognostic calculators. We will develop
prognostic models that estimate life expectancy, time to nursing home admission, and risk of death within 6
months for persons with Alzheimer's disease and related dementias in the nationally representative Health and
Retirement Study. We will externally validate these models using persons with Alzheimer's disease and
related dementias enrolled in the National Health and Aging Trends Study. After validation, these models can
be widely used to inform clinical and policy-level decisions for millions of Americans with Alzheimer's disease
and related dementias.

## Key facts

- **NIH application ID:** 10144348
- **Project number:** 5R01AG057751-04
- **Recipient organization:** NORTHERN CALIFORNIA INSTITUTE/RES/EDU
- **Principal Investigator:** Sei Lee
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $383,250
- **Award type:** 5
- **Project period:** 2018-08-15 → 2023-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10144348

## Citation

> US National Institutes of Health, RePORTER application 10144348, Prognostic calculators for patients with Alzheimers disease and related dementias (5R01AG057751-04). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10144348. Licensed CC0.

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