# Using electrical nerve stimulation to control atrial fibrillation

> **NIH NIH OT2** · CEDARS-SINAI MEDICAL CENTER · 2020 · $684,497

## Abstract

Study Plan: Using electrical nerve stimulation to control atrial fibrillation
Aim 1 will test the hypothesis that subcutaneous (Aim 1A) and transcutaneous (Aim 1B)
electrical nerve stimulation are effective in reducing the frequencies of paroxysmal atrial
fibrillation (AF) and the ventricular rate in patients with severe symptomatic AF unresponsive to
conventional therapies.
Aim 2 will test the hypothesis that in healthy subjects, electroacupuncture or TENS at LI-4 and
LI-11 can acutely activate or suppress skin sympathetic nerve activity (SKNA). We further
hypothesize that chronic TENS will reduce sympathetic output in humans. If confirmed,
repeated TENS may be used in the future clinical trials to control AF.

## Key facts

- **NIH application ID:** 10144598
- **Project number:** 7OT2OD028190-02
- **Recipient organization:** CEDARS-SINAI MEDICAL CENTER
- **Principal Investigator:** PENG-SHENG CHEN
- **Activity code:** OT2 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $684,497
- **Award type:** 7
- **Project period:** 2020-07-01 → 2025-02-28

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10144598

## Citation

> US National Institutes of Health, RePORTER application 10144598, Using electrical nerve stimulation to control atrial fibrillation (7OT2OD028190-02). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10144598. Licensed CC0.

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