# Administrative Core

> **NIH NIH P20** · WOMEN AND INFANTS HOSPITAL-RHODE ISLAND · 2021 · $673,822

## Abstract

Summary/Abstract
Complications of pregnancy including gestational diabetes mellitus, preeclampsia and preterm birth have all
been associated with future disease. Exciting preliminary data in Project 2 demonstrate an association if not a
causal link between preeclampsia and later risk of Alzheimer's disease. Likewise, the metabolic derangements
that accompany gestational diabetes (Projects 3) portend later risks of type 2 diabetes and metabolic
syndrome. In large population-based cohort studies, women with preeclampsia and preterm delivery have a
higher long-term risk of early death (themes of Projects 1-4). The goal of the Clinical and Translational
Research Core are to support investigations of the pathogenesis and mechanisms of these important
reproductive diseases. The insights from these projects will enhance our understanding and lead to novel
approaches to treatment, prediction and prevention. This Center of Biomedical Research Excellence (COBRE)
will develop a multidisciplinary, clinical/translational research program in Reproductive Health in Rhode Island.
This COBRE will provide an environment that fosters creative and trans-disciplinary approaches to study the
pathophysiology of pregnancy complications and their relationship to later health outcomes. This Core will
direct the identification, enrollment, consenting and collection of samples and data from identified cases and
controls in support of the projects in this COBRE.

## Key facts

- **NIH application ID:** 10145026
- **Project number:** 5P20GM121298-05
- **Recipient organization:** WOMEN AND INFANTS HOSPITAL-RHODE ISLAND
- **Principal Investigator:** SURENDRA SHARMA
- **Activity code:** P20 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $673,822
- **Award type:** 5
- **Project period:** 2017-04-01 → 2023-02-28

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10145026

## Citation

> US National Institutes of Health, RePORTER application 10145026, Administrative Core (5P20GM121298-05). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10145026. Licensed CC0.

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