# Mechanistic Studies of Lantibiotic Biosynthetic and Tailoring Enzymes

> **NIH NIH R01** · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · 2020 · $388,075

## Abstract

Project Summary/Abstract
Lantibiotics are ribosomally synthesized and post-translationally modified peptide natural
products. The biosynthetic enzymes that convert peptide substrates into constrained
antibiotics are not well understood, especially with regards to substrate recognition.
Here, we seek to carry out biochemical, and structural biological studies on several of
these enzymes and address questions regarding substrate recognition, and substrate
tolerance. We anticipate that this work will be of use not only towards the discovery of
new compounds but to enable the production of peptide-based compounds of any
structure.

## Key facts

- **NIH application ID:** 10145473
- **Project number:** 2R01GM079038-10A1
- **Recipient organization:** UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN
- **Principal Investigator:** Satish K Nair
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $388,075
- **Award type:** 2
- **Project period:** 2006-02-01 → 2024-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10145473

## Citation

> US National Institutes of Health, RePORTER application 10145473, Mechanistic Studies of Lantibiotic Biosynthetic and Tailoring Enzymes (2R01GM079038-10A1). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10145473. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*