# Multifunctional Nanoplatforms-Based Capture and identification of Circulating Tumor Biomarkers for  Early Diagnosis of Lung Cancer

> **NIH NIH U54** · JACKSON STATE UNIVERSITY · 2020 · $188,749

## Abstract

Significant disparities in incidence and mortality rates for lung cancer are reported 
among ethnically and racially diverse population. African Americans suffer from lung 
cancer more than any other population. High mortality rate in lung cancer is due to 
being diagnosed at a later stage, where treatment options are limited. Our long-term 
goal is to lay the groundwork for developing novel nanoplatform based device which 
will provide a more accurate determination of the circulating cancer biomarkers from 
lung cancer patients in blood screening facilities. The objective of this proposal is to 
design magnetic-fluorescence multifunctional nanoplatform based device to capture, 
isolate and detect circulating tumor cells (CTCs) and tumor derived exosomes from 
blood samples in lung cancer patients and to establish correlations of these findings 
with survival. Our central hypothesis is that bio-conjugated multicolor fluorescence 
carbon dots attached magnetic nano-platform can be used to capture multiple types 
of CTCs and circulating exosomes from blood samples, and as a facile multicolor 
fluorescence probe for accurate identification of circulating biomarkers. The central 
hypothesis will be tested by pursuing two specific aims: 1) Developing fluorescence- 
magnetic nanoplatform for capture, and identification of multiple types of CTCs from 
lung cancer patient blood and 2) Capture and identification of tumor derived 
exosomes using nanoplatform and demonstration of clinical applications. The 
proposed research is significant, because with high sensitivity and real-time 
detection possibility, CDs attached magnetic nano-platform will be highly promising 
for detection and identification of several subpopulation types of CTCs and 
exosomes. The proximate expected outcome of this work is improving the capability 
of identifying multiple clinically relevant blood based biomarkers in blood screening 
facilities.

## Key facts

- **NIH application ID:** 10145508
- **Project number:** 1U54MD015929-01
- **Recipient organization:** JACKSON STATE UNIVERSITY
- **Principal Investigator:** Paresh Chandra Ray
- **Activity code:** U54 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $188,749
- **Award type:** 1
- **Project period:** 2020-09-08 → 2025-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10145508

## Citation

> US National Institutes of Health, RePORTER application 10145508, Multifunctional Nanoplatforms-Based Capture and identification of Circulating Tumor Biomarkers for  Early Diagnosis of Lung Cancer (1U54MD015929-01). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10145508. Licensed CC0.

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