# Core A: Administrative Core

> **NIH NIH U19** · SCRIPPS FLORIDA · 2021 · $716,441

## Abstract

PROJECT SUMMARY (Core A – Administrative Core)
The general goals of this proposal are: (1) to establish robust, consistent, and safe states of ART-free
remission (‘functional cures’) in SHIV- and SIV-infected rhesus macaques through sustained expression of
antibodies and antibody-like inhibitors, (2) to understand the role of the macaque immune system and
antiretroviral therapy in facilitating these functional cures, and (3) to determine if these functional cures can
also help accelerate the decay of the reservoir of latently infected cells. The Administrative Core will
provide all the logistic, scientific, managerial, statistical, regulatory and financial support necessary to
facilitate and coordinate the studies of this program, thus ensuring the successful completion of these goals.
The Administrative Core will also establish and facilitate the activities of a Governing Committee with broad
experience in non-human primate studies and in the application of adeno-associated virus (AAV) vectors to
the treatment and prevention of viral infection. This Governing Committee will meet quarterly, twice with an
appointed Scientific Advisory and NIH Program officials, and twice independently. The Administrative Core
will facilitated these meetings. The Core will also promote cross-project collaborations by covering the
publication costs of all manuscripts involving multi-project collaborations central to the goals of this
proposal, and ensure statistical support for all studies described in this program. Finally the Core will
assume responsibility for compliance with animal care and use, financial, and reporting requirements
associated with this program.

## Key facts

- **NIH application ID:** 10145587
- **Project number:** 5U19AI149646-02
- **Recipient organization:** SCRIPPS FLORIDA
- **Principal Investigator:** Michael R. Farzan
- **Activity code:** U19 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $716,441
- **Award type:** 5
- **Project period:** 2020-04-15 → 2022-04-01

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10145587

## Citation

> US National Institutes of Health, RePORTER application 10145587, Core A: Administrative Core (5U19AI149646-02). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10145587. Licensed CC0.

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