# "Core C" Recombinant Virus Core

> **NIH NIH P01** · UNIVERSITY OF FLORIDA · 2021 · $126,723

## Abstract

Summary
The purpose of the Recombinant Virus Core C is to generate quality controlled recombinant
herpesviruses for KSHV, EBV, and MHV68 (Projects 1, 2 and 3). The services of Core C will aid the
overall goal of the program project to comprehensively analyze the role of herpesviral non-coding RNAs as
well as studies on host cellular lncRNAs that are perturbed in response to viral infection. In addition to
constructing recombinant viruses, Core C will perform genome-wide sequencing of viral mutants. Building
upon years of experience in making a complete set of KSHV miRNA deletion mutants, our group has
developed and implemented techniques for making bacmid-derived mutants in both KSHV and MHV68, and
will readily extend this to EBV.

## Key facts

- **NIH application ID:** 10145670
- **Project number:** 5P01CA214091-05
- **Recipient organization:** UNIVERSITY OF FLORIDA
- **Principal Investigator:** ROLF F RENNE
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $126,723
- **Award type:** 5
- **Project period:** 2017-02-09 → 2022-01-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10145670

## Citation

> US National Institutes of Health, RePORTER application 10145670, "Core C" Recombinant Virus Core (5P01CA214091-05). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10145670. Licensed CC0.

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