# Core B: Mouse Physiology and Surgery Core

> **NIH NIH P01** · TEMPLE UNIV OF THE COMMONWEALTH · 2021 · $316,998

## Abstract

Core B SUMMARY
The Mouse Physiology and Surgical Core (Core B) will be a focal point of the program by providing the
infrastructure to support numerous experimental approaches to assess cardiac physiology and pathology in the
intact animal. Utilizing the vast experience and expertise of the Core Director's, and well established and proven
protocols for the assessment of cardioprotection in multiple animal models. The Core will not only provide a
consistent and reproducible service in support of the projects but will further participate in experimental design,
prioritization of resources, and the interpretation of data. In addition, Core B will identify additional areas for
collaboration across all projects as the program matures and thus be central to the interactive environment and
comprehensive analysis of the overall platform as data is generated. The scientific core will provide a wide-range
of services pertinent to the overall success of the program including in providing multiple models of myocardial
injury to induce heart failure with also distant organ dysfunction such as cardiorenal syndrome. The core will also
be a resource to assist in cell and gene delivery to the heart and also the assessment of cardiac function via
echocardiography and catheter based hemodynamic measurement. Further, the core will be invaluable to assist
PPG investigators in the assessment of cardiac structure by multiple methodologies, and histological and
biochemical assessment of myocardial injury. These services will provide the backbone for all Projects of this
Program Project Grant to achieve their goals more efficiently.

## Key facts

- **NIH application ID:** 10145768
- **Project number:** 5P01HL147841-02
- **Recipient organization:** TEMPLE UNIV OF THE COMMONWEALTH
- **Principal Investigator:** Erhe Gao
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $316,998
- **Award type:** 5
- **Project period:** 2020-05-01 → 2025-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10145768

## Citation

> US National Institutes of Health, RePORTER application 10145768, Core B: Mouse Physiology and Surgery Core (5P01HL147841-02). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10145768. Licensed CC0.

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