# Clinical Research Sites for the MACS/WIHS Combined Cohort Study (MACS/WIHS-CCS) - Baltimore/Wash DC Center

> **NIH NIH U01** · JOHNS HOPKINS UNIVERSITY · 2020 · $34,073

## Abstract

Project Summary
 This application is for the renewal of the Study to Help the AIDS Research Effort (SHARE), which has
been the Baltimore-Washington DC site of the Multicenter AIDS Cohort Study (MACS) since 1984. The MACS
was established with sites in Baltimore-Washington, Chicago, Pittsburgh, and Los Angeles, initially to study the
natural history of HIV infection in men who have sex with men and later, with the advent of effective combination
antiretroviral therapy (cART), the treated history of HIV infection, including the relationship between long-term
controlled HIV infection and chronic diseases and co-morbidities associated with aging. To reflect these
changing priorities in HIV research, SHARE has had subsequent enrollments to balance proportions of HIV- and
HIV+ men and to reflect the HIV epidemic more accurately. Men enrolled have been followed semi annually
since 1984 or enrollment and have a) provided questionnaire data, physical exam data, laboratory data (including
HIV serostatus, T cell subset measurements, and HIV viral load measurements), and a large repository of
plasma, serum, cryopreserved peripheral blood mononuclear cells, and other specimens; and these have
permitted SHARE and MACS to make major contributions to the understanding of treated and untreated HIV
disease, and comorbidities associated with increased survival due to antiretroviral treatment.
 The present application, in response to RFA-HL-19-008, aims to extend followup of the SHARE cohort
(about 640 men) from 2019 to 2026, to allow merger of SHARE (and the other MACS sites) with the nine sites
of the Women’s Interagency HIV Study (WIHS) into a single cohort, termed the MACS-WIHS Combined Cohort
Study (CCS), that will include both men and women. The specific aims of the CCS are outlined in a parallel
application from the putative Data and Coordinating Center (DACC) of the CCS, and the 10 Specific Aims of that
single cohort are outlined in the DACC application for the CCS; these include Cardiovascular (CV),
Pulmonary/Sleep (PS), Neurocognitive NC), Aging (AG), Cancer, HIV Pathogenesis (PA), Psychosocial (PS),
Health Disparities, Platform (PL), and Career Development (CD) Aims. The specific aims of the SHARE Clinical
Research Site (CRS) are to: 1) play a leading role in the achievement 7 of these Aims by the CCS (i.e., CV, PS,
AG, PA, PS, PL, and CD), including serving as a reading center for echocardiography and sleep studies; 2) to
contribute to the achievement of the other 3 CCS aims, and 3) to implement all applicable CCS protocols and
support the scientific goals of the CCS. Local initiatives on inflammation and physical activity will also support
these aims, which take full advantage of the extensive follow-up and repository of biological specimens already
available from this cohort and which will be extended under this proposal, enabling further contributions to our
understanding and care of comorbidities and other health issues faced by people living with HIV...

## Key facts

- **NIH application ID:** 10145892
- **Project number:** 3U01HL146201-02S1
- **Recipient organization:** JOHNS HOPKINS UNIVERSITY
- **Principal Investigator:** TODD T BROWN
- **Activity code:** U01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $34,073
- **Award type:** 3
- **Project period:** 2020-07-01 → 2022-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10145892

## Citation

> US National Institutes of Health, RePORTER application 10145892, Clinical Research Sites for the MACS/WIHS Combined Cohort Study (MACS/WIHS-CCS) - Baltimore/Wash DC Center (3U01HL146201-02S1). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10145892. Licensed CC0.

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