# Administrative supplement to existing NIH R01 Quantitative proteomics of Zebrafish embryos and blastomeres

> **NIH NIH R01** · MICHIGAN STATE UNIVERSITY · 2020 · $69,950

## Abstract

Zebrafish is an important vertebrate model system for understanding early embryogenesis.
Genome analysis shows that 71% of human genes have at least one ortholog in zebrafish
and 82% of the known genes responsible for human disease are present in zebrafish.
Research on zebrafish embryos could shed invaluable light on human early embryogenesis.
There is a rich literature on transcriptome-wide changes that accompany zebrafish early
embryogenesis. However, transcriptome-level information is limited because zygotic
transcription is silent before the mid-blastula transition (MBT), because post-transcriptional
regulation modulates gene expression, and because protein post-translational modifications
(PTMs) influence protein function. We hypothesize that high time- and spatial-resolution
studies of the early-stage zebrafish proteome will provide new insights into early
embryogenesis.

## Key facts

- **NIH application ID:** 10145967
- **Project number:** 3R01GM125991-03S1
- **Recipient organization:** MICHIGAN STATE UNIVERSITY
- **Principal Investigator:** Liangliang Sun
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $69,950
- **Award type:** 3
- **Project period:** 2018-01-01 → 2022-12-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10145967

## Citation

> US National Institutes of Health, RePORTER application 10145967, Administrative supplement to existing NIH R01 Quantitative proteomics of Zebrafish embryos and blastomeres (3R01GM125991-03S1). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10145967. Licensed CC0.

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