# Mapping Immune Responses to CMV in Renal Transplant Recipients - Mechanistic Assays Core (UCSF)

> **NIH NIH U19** · UNIVERSITY OF CALIFORNIA LOS ANGELES · 2020 · $208,861

## Abstract

ABSTRACT
The COVID-19 clinical syndrome caused by the SARS-CoV-2 virus has the potential to cause significant
morbidity and mortality in previously healthy patients. A significant observation is that although this infection
may result in a self-limiting upper respiratory infection or mild pneumonia in some patients, other patients
experience progression of respiratory symptoms to requirement of intubation for mechanical respiratory
support and death due to severe respiratory failure. This clinical observation strongly suggests that differences
in host immunologic response are the determinative factor in clinical outcome. We hypothesize that the
proposed systems immunology, biostatistical and computational modeling approaches, coupled with detailed
clinical phenotype of hospitalized COVID-19 patients will provide a new framework to interpret the interplay
between SARS-CoV-2 virus and the host, and the relationship with clinical outcome. Project 1 will assess the
frequency and function of SARS-CoV-2 virus antigen specific T cells and evaluate their breadth and clonality
of their TCR repertoire with clinical outcome. Project 2 will determine epigenetic signatures of the immune
response to the SARS-CoV-2 virus across short, middle and long-term times and identify DNA methylation-
based markers of anti-viral immunity and clinical outcome. With this approach, we will create a unique resource
of highly annotated longitudinal data on SARS-CoV-2 virus infection, which will enable the development of
novel diagnostic strategies and therapeutics to treat or prevent SARS-CoV-2 virus infection.

## Key facts

- **NIH application ID:** 10146167
- **Project number:** 3U19AI128913-03S3
- **Recipient organization:** UNIVERSITY OF CALIFORNIA LOS ANGELES
- **Principal Investigator:** ELAINE F REED
- **Activity code:** U19 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $208,861
- **Award type:** 3
- **Project period:** 2020-07-22 → 2021-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10146167

## Citation

> US National Institutes of Health, RePORTER application 10146167, Mapping Immune Responses to CMV in Renal Transplant Recipients - Mechanistic Assays Core (UCSF) (3U19AI128913-03S3). Retrieved via AI Analytics 2026-05-21 from https://api.ai-analytics.org/grant/nih/10146167. Licensed CC0.

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