# T cells mediate age related arterial dysfunction

> **NIH NIH K01** · UNIVERSITY OF TEXAS ARLINGTON · 2021 · $126,900

## Abstract

PROJECT SUMMARY
Candidate: Daniel Trott, Ph.D. is an Assistant Professor at the University of Texas at Arlington. Dr. Trott's
research is focused on the interaction between inflammation and age-related arterial dysfunction. Dr. Trott's
long-term goal is to independently direct an extramurally funded laboratory with research focused on the
interaction of the aging immune system and vasculature in both pre-clinical models and in humans.
Career Development: This award will support Dr. Trott's career development by building on his existing
training in aging and vascular biology. Specifically, Dr. Trott will receive extensive training in the planning and
execution of studies assessing vascular and immune outcomes in older adults. The career development plan
outlines a coordinated effort to train the candidate in areas including: vascular biology of aging, assessment of
vascular function in humans, human endothelial cell and immune cell phenotyping, and, attendance at regular
aging and vascular seminar series as well as other meetings within the university and nationally.
Environment: The University of Texas at Arlington is an ideal environment for Dr. Trott's career development.
This environment provides all of the resources needed to complete the proposed studies. Further, his
mentoring team allows for collaboration with experts in aging, vascular biology, and immunology. The
University of Texas at Arlington also provides a rich environment for formal and informal training in career
development.
Research: The central hypothesis of this research project is that T cells mediate age-related arterial
dysfunction. First, we hypothesize that T cells infiltrate the perivascular tissue around large elastic and
resistance arteries and mediate age-related arterial dysfunction. To test this, we will assess arterial function,
immune cell infiltration and inflammatory subtypes in young and old mice with T cells intact or depleted. In
addition, we will employ adoptive transfer to determine whether aged T cells preferentially home to the
vasculature and induce dysfunction. Second, we hypothesize that T cells directly mediate age-related arterial
dysfunction in older adults. To test this hypothesis we will adoptively transfer T cells from young, middle aged
and older healthy human donors to NOD-scid/γcnull/A2 humanized mice and assess immune cell infiltration,
inflammation and arterial function. We will also assess arterial function, plasma free radicals and endothelial
and T cell phenotype in the human donors to determine the relationship between these parameters and the
degree of dysfunction induced in the recipient mice. The results from these studies will provide insight into the
etiology of age-related arterial dysfunction and identify previously unexplored targets for diagnostics and
intervention with the significant goal of maintaining cardiovascular health in the elderly.

## Key facts

- **NIH application ID:** 10146264
- **Project number:** 5K01AG061271-03
- **Recipient organization:** UNIVERSITY OF TEXAS ARLINGTON
- **Principal Investigator:** Daniel Trott
- **Activity code:** K01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $126,900
- **Award type:** 5
- **Project period:** 2019-04-15 → 2024-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10146264

## Citation

> US National Institutes of Health, RePORTER application 10146264, T cells mediate age related arterial dysfunction (5K01AG061271-03). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10146264. Licensed CC0.

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