# Dissecting Gastrointestinal Endocrine Cell Signaling

> **NIH NIH R01** · WASHINGTON UNIVERSITY · 2021 · $397,187

## Abstract

PROJECT SUMMARY/ABSTRACT
The Drosophila midgut provides a useful model for understanding the mammalian gastrointestinal tract. Great progress has been made in associating specific configurations of our gut microbial communities with distinct physiological states. Yet, precisely how enteroendocrine cells, which are embedded in the gut epithelium sense luminal contents is less well understood. Our preliminary studies have laid the foundation for a powerful new Drosophila model of the enteroendocrine system. These observations raise the central hypothesis that endocrine cells signal over a long-range to control homeostasis of distant tissues. We propose to define the factors influencing luminal sensing by the enteroendocrine cell population. This question is currently difficult to address in mammals, as the tools for conditionally manipulating both endocrine cell subtypes and peripheral target tissues with single cell resolution have not yet been established. Thus, we propose to use Drosophila as a model to dissect mechanisms controlling the endocrine system.

## Key facts

- **NIH application ID:** 10146360
- **Project number:** 5R01DK117335-04
- **Recipient organization:** WASHINGTON UNIVERSITY
- **Principal Investigator:** Craig A Micchelli
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $397,187
- **Award type:** 5
- **Project period:** 2018-06-01 → 2022-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10146360

## Citation

> US National Institutes of Health, RePORTER application 10146360, Dissecting Gastrointestinal Endocrine Cell Signaling (5R01DK117335-04). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10146360. Licensed CC0.

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