# Integrative Health Sciences Facility Core

> **NIH NIH P30** · UNIVERSITY OF IOWA · 2021 · $171,460

## Abstract

PROJECT SUMMARY – INTEGRATIVE HEALTH SCIENCES FACILITY 
The overall goal of the Integrative Health Sciences Facility (IHSF) is to encourage, support and enhance 
clinical and translational studies relevant to environmental health sciences. In addition, through our state-of- 
the-art imaging facility we provide investigators with cutting edge technology to evaluate and analyze effects 
of ambient air pollutants on lung structures. This technology can be applied to small animals such as rodents, 
large animals such as pigs, and humans, promoting translation of basic discoveries related to environmental 
exposures to humans. To accomplish this goal, the IHSF will, 1) Provide the infrastructure to carry out clinical 
and translational studies relevant to environmental health sciences; 2) Ensure that clinical and translational 
studies are carried out safely and that subject confidentially is maintained; 3) Provide the infrastructure for 
training of young clinical/translational investigators with an interest in environmental health sciences; and 4) 
Support EHSRC investigators who utilize the Institute for Clinical and Translational Science (ICTS) and 
promote new multidisciplinary research collaborations. The facility services are focused on three main areas: 
recruitment, evaluation and assessment of research subjects. To support these areas, we have a Research 
Subject Recruitment and Interactions Component, Imaging Component, Cardiopulmonary Physiology 
Component, and Biologic Sampling Component. The IHSF facilitates the use of University of Iowa resources, 
specifically the ICTS Clinical Research Unit, the Cardiovascular Human Physiology Laboratory, the ICTS 
Core Analytical Laboratory, the ICTS Research Safety Office, and the Clinical Bronchoscopy Suite. In future 
initiatives we will support the infrastructure to enhance collaboration between diverse researchers (from the 
Colleges of Public Health, Medicine, Engineering, Pharmacy, and Liberal Arts and Sciences) with a common 
interest in environmentally and genetically influenced, inflammatory-associated lung pathologies, including 
COPD, asthma, cystic fibrosis, occupational lung diseases, and cancer. We are developing an informatics 
service to harmonize lung-imaging protocols throughout the University of Iowa Healthcare Network so that we 
can rapidly expand our imaging database and its utility for research studies. This unique dataset will provide 
the opportunity to test hypotheses related to the contributions that environmental exposures have to the 
development of lung diseases. This research using imaging to define meaningful functional and structural 
phenotypic expressions linking environmental and genetic factors to lung disease is highly relevant to the 
goals of the Environmental Health Sciences Research Center. The Integrative Health Sciences Facility 
represents a critical resource to facilitate the conduct of clinical and translational research studies within the 
EHSRC.

## Key facts

- **NIH application ID:** 10146856
- **Project number:** 5P30ES005605-31
- **Recipient organization:** UNIVERSITY OF IOWA
- **Principal Investigator:** ALEJANDRO Pierre COMELLAS
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $171,460
- **Award type:** 5
- **Project period:** 1997-04-01 → 2022-06-16

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10146856

## Citation

> US National Institutes of Health, RePORTER application 10146856, Integrative Health Sciences Facility Core (5P30ES005605-31). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10146856. Licensed CC0.

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