# Novel Multiple-Stage Active Antimalarials

> **NIH NIH R01** · PORTLAND STATE UNIVERSITY · 2021 · $620,053

## Abstract

PROJECT SUMMARY/ABSTRACT
 Natural products have been notably at the forefront of most approaches to combating many infectious
diseases. Many of the natural products have served as template for the design and development of
antimalarial drugs currently in the clinic or in the development phase. Recently we have developed a series of
novel antimalarial chemical entities inspired by the prodiginine and tambjamine natural products that meet the
following key criteria: 1) potent activities against liver stage and blood stage malaria parasites, as well as
inhibition of gamete formation; 2) orally efficacious; 3) curative in a single dose; 4) fast-acting; 5) long duration
of coverage; and 6) unique chemotype as compared to existing antimalarials likely operate by a novel
mechanism(s) of action. The ability to combat multiple stages of the infection with the potential of transmission
blocking represents a powerful tool, and one ideally suited to achieve the broadest possible benefit as a
renewed malaria eradication effort proceeds. Our proposed work in this application seeks to develop novel,
potent, safe, and inexpensive antimalarial drugs for both prevention and treatment of malaria, thus supporting
world-wide elimination of the disease. The specific goal of this project is to conduct lead optimization studies to
produce lead candidates for full preclinical testing that retain the broad-spectrum features and demonstrate
enhanced efficacy, safety and pharmacokinetic profiles that warrant further development.

## Key facts

- **NIH application ID:** 10146947
- **Project number:** 5R01AI141972-03
- **Recipient organization:** PORTLAND STATE UNIVERSITY
- **Principal Investigator:** JANE X KELLY
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $620,053
- **Award type:** 5
- **Project period:** 2019-06-14 → 2024-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10146947

## Citation

> US National Institutes of Health, RePORTER application 10146947, Novel Multiple-Stage Active Antimalarials (5R01AI141972-03). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10146947. Licensed CC0.

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