# Core A - Bioinformatics Core

> **NIH NIH P01** · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · 2021 · $114,999

## Abstract

SUMMARY – CORE A 
The four research projects of the Program Project propose laboratory characterization of the consequences of 
genetic variation for carcinogenesis and cancer therapy. These studies are focused on genes involved in Base 
Excision Repair (BER). Genetic variation will include germline and somatic variation. Core A will provide 
informatics and statistics support for these experiments. Core A personnel have expertise in bioinformatics, 
systems biology, statistics, process management, and high performance computing. Dr. Bond has worked with 
the P01 since its inception. Aim 1 (Informatics) Identify variants for functional studies. A central role of 
Core A is to support identification of variants, for experimental studies, that are expected to have 
consequences for protein function. These variants are identified using DNA sequences available from large- 
scale sequence projects such as the 1000 Genomes Project and The Cancer Genome Atlas. Core A 
annotates the variants using publicly available software. Core A (Drs. Bond and Dragon) host weekly meetings 
at which these variants are presented and discussed. These meetings provide consistent communications with 
members of the four projects. Aim 2 (Statistics) Provide software and statistical support for hypothesis 
tests. The laboratory studies proposed in Projects 1-4 will characterize the consequences of this variation for 
protein structure, interactions, damage search and catalysis as well as cellular proliferation and survival. Core 
A statistical services will support design and analysis of these experiments.

## Key facts

- **NIH application ID:** 10146958
- **Project number:** 5P01CA098993-15
- **Recipient organization:** UNIVERSITY OF VERMONT & ST AGRIC COLLEGE
- **Principal Investigator:** Julie Dragon
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $114,999
- **Award type:** 5
- **Project period:** 2004-09-03 → 2025-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10146958

## Citation

> US National Institutes of Health, RePORTER application 10146958, Core A - Bioinformatics Core (5P01CA098993-15). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10146958. Licensed CC0.

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